Shuen-Ing Tschen
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Explore the profile of Shuen-Ing Tschen including associated specialties, affiliations and a list of published articles.
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11
Citations
875
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Recent Articles
1.
Tschen S, Zeng C, Field L, Dhawan S, Bhushan A, Georgia S
Cell Cycle
. 2017 Aug;
16(22):2183-2191.
PMID: 28763258
Diabetes results from an inadequate mass of functional β cells, due to either β cell loss caused by autoimmune destruction (type I diabetes) or β cell failure in response to...
2.
Dhawan S, Tschen S, Zeng C, Guo T, Hebrok M, Matveyenko A, et al.
J Clin Invest
. 2015 Jun;
125(7):2851-60.
PMID: 26098213
Pancreatic β cells secrete insulin in response to postprandial increases in glucose levels to prevent hyperglycemia and inhibit insulin secretion under fasting conditions to protect against hypoglycemia. β cells lack...
3.
Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming
Papizan J, Singer R, Tschen S, Dhawan S, Friel J, Hipkens S, et al.
Genes Dev
. 2011 Nov;
25(21):2291-305.
PMID: 22056672
Regulation of cell differentiation programs requires complex interactions between transcriptional and epigenetic networks. Elucidating the principal molecular events responsible for the establishment and maintenance of cell fate identities will provide...
4.
Tschen S, Georgia S, Dhawan S, Bhushan A
Mol Endocrinol
. 2011 Oct;
25(12):2134-43.
PMID: 21980072
The glucoincretin hormone glucagon-like peptide-1 (GLP-1) and its analog exendin-4 (Ex-4) promote β-cell growth and expansion. Here we report an essential role for Skp2, a substrate recognition component of SCF...
5.
Dhawan S, Georgia S, Tschen S, Fan G, Bhushan A
Dev Cell
. 2011 Apr;
20(4):419-29.
PMID: 21497756
Adult pancreatic β cells can replicate during growth and after injury to maintain glucose homeostasis. Here, we report that β cells deficient in Dnmt1, an enzyme that propagates DNA methylation...
6.
Dhawan S, Tschen S, Bhushan A
Genes Dev
. 2009 Apr;
23(8):906-11.
PMID: 19390085
The molecular mechanisms that regulate the age-induced increase of p16(INK4a) expression associated with decreased beta-cell proliferation and regeneration are not well understood. We report that in aged islets, derepression of...
7.
Tschen S, Dhawan S, Gurlo T, Bhushan A
Diabetes
. 2009 Feb;
58(6):1312-20.
PMID: 19228811
Objective: The aim of this study was to elucidate whether age plays a role in the expansion or regeneration of beta-cell mass. Research Design And Methods: We analyzed the capacity...
8.
Zhong L, Georgia S, Tschen S, Nakayama K, Nakayama K, Bhushan A
J Clin Invest
. 2007 Sep;
117(10):2869-76.
PMID: 17823659
Diabetes results from an inadequate mass of functional beta cells, due to either beta cell loss caused by immune assault or the lack of compensation to overcome insulin resistance. Elucidating...
9.
Tschen S, Stohlman S, Ramakrishna C, Hinton D, Atkinson R, Bergmann C
Eur J Immunol
. 2006 Jan;
36(3):603-12.
PMID: 16437540
Neurotropic coronavirus infection of mice results in acute encephalomyelitis followed by viral persistence. Whereas cellular immunity controls acute infection, humoral immunity regulates central nervous system (CNS) persistence. Maintenance of serum...
10.
Stohlman S, Ramakrishna C, Tschen S, Hinton D, Bergmann C
J Neurovirol
. 2002 Dec;
8 Suppl 2:53-8.
PMID: 12491152
Central nervous system infection by the neurotropic JHM strain of mouse hepatitis virus (JHMV) results in chronic demyelination characterized by viral persistence in the absence of infectious virus. CD8(+) T...