Shuang-Yong Xu
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Explore the profile of Shuang-Yong Xu including associated specialties, affiliations and a list of published articles.
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71
Citations
1408
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Recent Articles
1.
Sen S, Esteve P, Raman K, Beaulieu J, Chin H, Feehery G, et al.
Nucleic Acids Res
. 2025 Jan;
53(2).
PMID: 39817518
Gene expression is regulated by chromatin DNA methylation and other features, including histone post-translational modifications (PTMs), chromatin remodelers and transcription factor occupancy. A complete understanding of gene regulation will require...
2.
Szafran K, Rafalski D, Skowronek K, Wojciechowski M, Kazrani A, Gilski M, et al.
Nucleic Acids Res
. 2024 Jul;
52(15):9103-9118.
PMID: 39041409
The BisI family of restriction endonucleases is unique in requiring multiple methylated or hydroxymethylated cytosine residues within a short recognition sequence (GCNGC), and in cleaving directly within this sequence, rather...
3.
Helbrecht I, Heiter D, Yang W, Vincze T, Hanneman A, Lutz T, et al.
Front Microbiol
. 2024 Apr;
15:1286822.
PMID: 38655080
Winged helix (wH) domains, also termed winged helix-turn-helix (wHTH) domains, are widespread in all kingdoms of life and have diverse roles. In the context of DNA binding and DNA modification...
4.
Chin H, Vishnu U, Sun Z, Ponnaluri V, Zhang G, Xu S, et al.
Methods Mol Biol
. 2023 Feb;
2611:39-52.
PMID: 36807062
Genome-wide accessible chromatin sequencing and identification has enabled deciphering the epigenetic information encoded in chromatin, revealing accessible promoters, enhancers, nucleosome positioning, transcription factor occupancy, and other chromosomal protein binding. The...
5.
Yang W, Fomenkov A, Heiter D, Xu S, Ettwiller L
PLoS Genet
. 2022 Sep;
18(9):e1010389.
PMID: 36121836
Phosphorothioation (PT), in which a non-bridging oxygen is replaced by a sulfur, is one of the rare modifications discovered in bacteria and archaea that occurs on the sugar-phosphate backbone as...
6.
Gidwani S, Heiter D, Xu S
Front Microbiol
. 2022 Jun;
13:888435.
PMID: 35663886
It is stated that XI is a Type IIB restriction endonuclease (REase) that cleaves both sides of its recognition sequence 5'↓N9 AC N5 CTCC N10↓ 3' (complement strand 5' ↓N7...
7.
Xu S
Front Microbiol
. 2022 Feb;
12:787073.
PMID: 35178039
Strand-specific DNA nicking endonucleases (NEases) typically nick 3-7 bp sites. Our goal is to engineer infrequent NEase with a >8 bp recognition sequence. A HI catalytic-deficient mutant D94N/E113K was constructed,...
8.
Xu S, Zemlyanskaya E, Gonchar D, Sun Z, Weigele P, Fomenkov A, et al.
Front Microbiol
. 2021 Jul;
12:689929.
PMID: 34276622
BisI is a sequence-specific and 5-methylcytosine (m5C)-dependent restriction endonuclease (REase), that cleaves the modified DNA sequence Gm5CNGC (G indicates that the cytosine opposite to G is modified). We expressed and...
9.
Xu S, Fomenkov A, Chen T, Yigit E
Front Microbiol
. 2021 Jun;
12:660149.
PMID: 34177838
The SARS-CoV-2 viral genome contains a positive-strand single-stranded RNA of ∼30 kb. Human ACE2 protein is the receptor for SARS-CoV-2 virus attachment and infection. We propose to use ribonucleases (RNases)...
10.
Tumuluri V, Rajgor V, Xu S, Chouhan O, Saikrishnan K
Nucleic Acids Res
. 2021 Feb;
49(4):2161-2178.
PMID: 33533920
Acquisition of foreign DNA by Staphylococcus aureus, including vancomycin resistance genes, is thwarted by the ATP-dependent endonuclease SauUSI. Deciphering the mechanism of action of SauUSI could unravel the reason how...