Shirley J Peters
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Explore the profile of Shirley J Peters including associated specialties, affiliations and a list of published articles.
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5
Citations
69
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Recent Articles
1.
Sopp J, Peters S, Rowley T, Oldham R, James S, Mockridge I, et al.
Commun Biol
. 2021 Sep;
4(1):1031.
PMID: 34475514
The majority of depleting monoclonal antibody (mAb) drugs elicit responses via Fc-FcγR and Fc-C1q interactions. Optimal C1q interaction is achieved through hexameric Fc:Fc interactions at the target cell surface. Herein...
2.
Bhatta P, Whale K, Sawtell A, Thompson C, Rapecki S, Cook D, et al.
MAbs
. 2021 Jan;
13(1):1859049.
PMID: 33487120
Bispecific antibodies can uniquely influence cellular responses, but selecting target combinations for optimal functional activity remains challenging. Here we describe a high-throughput, combinatorial, phenotypic screening approach using a new bispecific...
3.
Rowley T, Peters S, Aylott M, Griffin R, Davies N, Healy L, et al.
Commun Biol
. 2018 Oct;
1:146.
PMID: 30272022
Autoantibody-mediated diseases are currently treated with intravenous immunoglobulin, which is thought to act in part via blockade of Fc gamma receptors, thereby inhibiting autoantibody effector functions and subsequent pathology. We...
4.
Pacholarz K, Peters S, Garlish R, Henry A, Taylor R, Humphreys D, et al.
Chembiochem
. 2015 Nov;
17(1):46-51.
PMID: 26534882
The aggregation of protein-based therapeutics such as monoclonal antibodies (mAbs) can affect the efficacy of the treatment and can even induce effects that are adverse to the patient. Protein engineering...
5.
Peters S, Smales C, Henry A, Stephens P, West S, Humphreys D
J Biol Chem
. 2012 May;
287(29):24525-33.
PMID: 22610095
The integrity of antibody structure, stability, and biophysical characterization are becoming increasingly important as antibodies receive increasing scrutiny from regulatory authorities. We altered the disulfide bond arrangement of an IgG4...