Sonya James
Overview
Explore the profile of Sonya James including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
533
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Recent Articles
1.
Simpson A, Oldham R, Cox K, Taylor M, James S, White A, et al.
Clin Exp Immunol
. 2025 Mar;
PMID: 40089806
Fc receptors (FcR) play a key role in coordinating responses from both the innate and adaptive immune system. The inhibitory Fc gamma receptor (FcγRIIB/CD32B; referred to as FcγRII in mice)...
2.
Yu X, Orr C, Chan H, James S, Penfold C, Kim J, et al.
Nature
. 2023 Feb;
614(7948):539-547.
PMID: 36725933
Antibody responses during infection and vaccination typically undergo affinity maturation to achieve high-affinity binding for efficient neutralization of pathogens. Similarly, high affinity is routinely the goal for therapeutic antibody generation....
3.
Mellone M, Piotrowska K, Venturi G, James L, Bzura A, Lopez M, et al.
Cancer Res
. 2022 Nov;
82(24):4571-4585.
PMID: 36353752
Significance: ATM signaling supports the differentiation of myoCAFs to suppress T-cell infiltration and antitumor immunity, supporting the potential clinical use of ATM inhibitors in combination with checkpoint inhibition in myoCAF-rich,...
4.
Webb E, Moreno-Vincente J, Easton A, Lanati S, Taylor M, James S, et al.
iScience
. 2022 Sep;
25(9):104995.
PMID: 36097618
The outcome for children with high-risk neuroblastoma is poor despite intensive multi-modal treatment protocols. Toxicity from current treatments is significant, and novel approaches are needed to improve outcome. Cyclophosphamide (CPM)...
5.
Simpson A, Roghanian A, Oldham R, Chan H, Penfold C, Kim H, et al.
Cell Rep
. 2022 Jul;
40(3):111099.
PMID: 35858562
Many therapeutic antibodies deplete target cells and elicit immunotherapy by engaging activating Fc gamma receptors (FcγRs) on host effector cells. These antibodies are negatively regulated by the inhibitory FcγRIIB (CD32B)....
6.
Hussain K, Liu R, Smith R, Muller K, Ghorbani M, Macari S, et al.
J Exp Clin Cancer Res
. 2022 Apr;
41(1):131.
PMID: 35392965
Background: Hypoxia is a hallmark of the tumor microenvironment (TME) and in addition to altering metabolism in cancer cells, it transforms tumor-associated stromal cells. Within the tumor stromal cell compartment,...
7.
Sopp J, Peters S, Rowley T, Oldham R, James S, Mockridge I, et al.
Commun Biol
. 2021 Sep;
4(1):1031.
PMID: 34475514
The majority of depleting monoclonal antibody (mAb) drugs elicit responses via Fc-FcγR and Fc-C1q interactions. Optimal C1q interaction is achieved through hexameric Fc:Fc interactions at the target cell surface. Herein...
8.
Yu X, James S, Felce J, Kellermayer B, Johnston D, Chan H, et al.
Commun Biol
. 2021 Jun;
4(1):772.
PMID: 34162985
Monoclonal antibodies (mAb) and natural ligands targeting costimulatory tumor necrosis factor receptors (TNFR) exhibit a wide range of agonistic activities and antitumor responses. The mechanisms underlying these differential agonistic activities...
9.
Sparrow E, James S, Hussain K, Beers S, Cragg M, Bogdanov Y
PLoS One
. 2021 May;
16(5):e0251632.
PMID: 34014994
Background: The major sites for fast synaptic inhibition in the central nervous system (CNS) are ion channels activated by γ-aminobutyric acid (GABA). These receptors are referred as GABA(A) receptors (GABA(A)R)....
10.
Webb E, Lanati S, Wareham C, Easton A, Dunn S, Inzhelevskaya T, et al.
Sci Rep
. 2020 Oct;
10(1):16695.
PMID: 33028899
Immunotherapy offers a potentially less toxic, more tumor-specific treatment for neuroblastoma than conventional cytotoxic therapies. Accurate and reproducible immune competent preclinical models are key to understanding mechanisms of action, interactions...