Shinya Tsutsumi
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Explore the profile of Shinya Tsutsumi including associated specialties, affiliations and a list of published articles.
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8
Citations
86
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Recent Articles
1.
Horie M, Morita K, Kawakami J, Tsutsumi S, Ando O, Koizumi M
Nucleic Acids Symp Ser (Oxf)
. 2006 Dec;
(49):171-2.
PMID: 17150688
Oligonucleotides uniformly modified with 2'-O,4'-C-ethylene-bridged nucleic acid (ENA) units were synthesized using the phosphoramidite method on a hundred-milligram scale for the evaluation of thermodynamic and chemical properties. The properties of...
2.
Koizumi M, Takagi-Sato M, Okuyama R, Araki K, Sun W, Nakai D, et al.
Oligonucleotides
. 2006 Sep;
16(3):253-62.
PMID: 16978088
Protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity of the 2'-O-(2-methoxy)ethyl (2'- MOE)-modified gapmer antisense oligonucleotide, ISIS113715, was previously reported. This antisense oligonucleotide increases insulin sensitivity and normalizes plasma glucose levels in...
3.
Horie M, Morita K, Kawakami J, Ando O, Koizumi M, Tsutsumi S
Nucleosides Nucleotides Nucleic Acids
. 2006 Apr;
25(3):231-42.
PMID: 16629117
Synthesis and properties of an oligonucleotide uniformly modified with 2'-O,4-C-ethylene-bridged nucleic acid (ENA) units were compared with those of GRN163, which is modified with N3'-P5' thiophosphoramidates, with the sequence targeting...
4.
Koizumi M, Morita K, Daigo M, Tsutsumi S, Abe K, Obika S, et al.
Nucleic Acids Res
. 2003 Jun;
31(12):3267-73.
PMID: 12799454
Antigenes, which are substances that inhibit gene expression by binding to double-stranded DNA (dsDNA) in a sequence-specific manner, are currently sought for the treatment of various gene-related diseases. As such...
5.
Muramatsu Y, Muramatsu A, Ohnuki T, Ishii M, Kizuka M, Enokita R, et al.
J Antibiot (Tokyo)
. 2003 May;
56(3):243-52.
PMID: 12760680
In the course of our screening for bacterial phospho-N-acetylmuramyl-pentapeptide-translocase (translocase I: EC 2.7.8.13) inhibitors, we found inhibitory activity in the cultured broth of the strain identified as Streptomyces griseus SANK...
6.
Morita K, Takagi M, Hasegawa C, Kaneko M, Tsutsumi S, Sone J, et al.
Bioorg Med Chem
. 2003 Apr;
11(10):2211-26.
PMID: 12713831
Novel bicyclo nucleosides, 2'-O,4'-C-ethylene nucleosides and 2'-O,4'-C-propylene nucleosides, were synthesized as building blocks for antisense oligonucleotides to further optimize the 2'-O,4'-C-methylene-linkage of bridged nucleic acids (2',4'-BNA) or locked nucleic acids...
7.
Suzuki N, Takemura A, Miyamoto A, Yoshioka T, Tsutsumi S, Kawasaki T
J Pharm Biomed Anal
. 2002 Oct;
30(3):823-36.
PMID: 12367708
A simple HPLC method for the direct chiral separation of troglitazone stereoisomers was developed. The separation was performed on a reversed-phase cellulose-derivertized chiral column (Chiralcel OJ-R) using a mobile phase...
8.
Morita K, Hasegawa C, Kaneko M, Tsutsumi S, Sone J, Ishikawa T, et al.
Bioorg Med Chem Lett
. 2001 Dec;
12(1):73-6.
PMID: 11738576
To develop antisense oligonucleotides, novel nucleosides, 2'-O,4'-C-ethylene nucleosides and their corresponding phosphoramidites, were synthesized as building blocks. The 1H NMR analysis showed that the 2'-O,4'-C-ethylene linkage of these nucleosides restricts...