Takeshi Imanishi
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Explore the profile of Takeshi Imanishi including associated specialties, affiliations and a list of published articles.
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111
Citations
592
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Recent Articles
1.
Hattori S, Mugiya S, Kurita Y, Sato S, Imanishi T, Kasugai S
Hinyokika Kiyo
. 2021 Feb;
67(1):11-15.
PMID: 33535291
A 70-year-old man complaining of pain in his right leg presented to the Department of Orthopedics in our hospital. X-ray findings revealed calcifications around the left kidney. He was referred...
2.
Fujisaka A, Hari Y, Takuma H, Rahman S, Yoshikawa H, Pang J, et al.
Bioorg Med Chem
. 2019 Mar;
27(8):1728-1741.
PMID: 30862430
We efficiently synthesized 2'-O,4'-C-aminomethylene-bridged nucleic acid (2',4'-BNA) monomers bearing the four nucleobases, guanine, adenine, thymine, and 5-methylcytosine and incorporated these monomers into oligonucleotides. Initially, we carried out the transglycosylation reaction...
3.
Obika S, Hari Y, Sekiguchi M, Imanishi T
Angew Chem Int Ed Engl
. 2018 May;
40(11):2079-2081.
PMID: 29712196
Significantly enhanced binding affinity to C⋅G base pairs without loss of sequence selectivity is achieved by using a nucleotide containing a 2-pyridone and a 2'-O,4'-C-methylene-bridged nucleic acid analogue (P ,...
4.
Mukai H, Ozaki D, Cui Y, Kuboyama T, Yamato-Nagata H, Onoe K, et al.
J Control Release
. 2014 Feb;
180:92-9.
PMID: 24566256
Recently, we demonstrated the utility of positron emission tomography (PET) imaging-based pharmacokinetic evaluation studies for preclinical experiments and microdose clinical trials, mainly focused on low molecular weight compounds. In order...
5.
Itoh M, Nakaura M, Imanishi T, Obika S
Nucleic Acid Ther
. 2014 Jan;
24(3):186-91.
PMID: 24460393
Gene knockdowns using oligonucleotide-based approaches are useful for studying gene function in both in vitro cell culture systems and in vivo animal models. We evaluated the efficacy of 2',4'-bridged nucleic...
6.
Suzuki T, Furuse H, Kurita Y, Imanishi T, Tamura K, Otsuka A, et al.
Nihon Hinyokika Gakkai Zasshi
. 2013 Jul;
104(3):549-53.
PMID: 23819370
We report a case of clear cell adenocarcinoma of the female urethra. A 57-year-old woman presented with complaint of gross hematuria. Abdominal ultrasonography, cystourethroscopy, computed tomography (CT) and magnetic resonance...
7.
Yamamoto T, Harada-Shiba M, Nakatani M, Wada S, Yasuhara H, Narukawa K, et al.
Mol Ther Nucleic Acids
. 2013 Jan;
1:e22.
PMID: 23344002
Recent findings in molecular biology implicate the involvement of proprotein convertase subtilisin/kexin type 9 (PCSK9) in low-density lipoprotein receptor (LDLR) protein regulation. The cholesterol-lowering potential of anti-PCSK9 antisense oligonucleotides (AONs)...
8.
Yamamoto T, Yasuhara H, Wada F, Harada-Shiba M, Imanishi T, Obika S
J Nucleic Acids
. 2012 Oct;
2012:707323.
PMID: 23056920
The duplex stability with target mRNA and the gene silencing potential of a novel bridged nucleic acid analogue are described. The analogue, 2',4'-BNA(NC) antisense oligonucleotides (AONs) ranging from 10- to...
9.
Ikejiri M, Tsuchino M, Chihara Y, Yamaguchi T, Imanishi T, Obika S, et al.
Org Lett
. 2012 Aug;
14(17):4406-9.
PMID: 22897798
A small molecular model compound for the green fluorescent protein chromophore was readily synthesized by a novel condensation reaction of (thio)imidate with imino-ester via an aziridine intermediate. This compound showed...
10.
Kawada Y, Kodama T, Miyashita K, Imanishi T, Obika S
Org Biomol Chem
. 2012 May;
10(26):5102-8.
PMID: 22614066
Previously, we reported that the 3,4-epoxypiperidine structure, whose design was based on the active site of DNA alkylating antitumor antibiotics, azinomycins A and B, possesses prominent DNA cleavage activity. In...