Shinichi Nishimura
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Explore the profile of Shinichi Nishimura including associated specialties, affiliations and a list of published articles.
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67
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1330
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Recent Articles
11.
Nishimura S
J Antibiot (Tokyo)
. 2021 Sep;
74(11):769-785.
PMID: 34493848
The cell membrane, with high fluidity and alternative curvatures, maintains the robust integrity to distinguish inner and outer space of cells or organelles. Lipids are the main components of the...
12.
Ueno R, Nishimura S, Fujimoto G, Ainiwaer D
Curr Med Res Opin
. 2021 May;
37(7):1121-1134.
PMID: 33989102
Objective: To examine treatment patterns of real-world antifungal management of patients at high risk of invasive fungal infections (IFI) and evaluate healthcare resource utilization and costs associated with antifungal management...
13.
Fujita K, Ikuta M, Nishimura S, Sugiyama R, Yoshimura A, Kakeya H
J Nat Prod
. 2021 Mar;
84(4):986-992.
PMID: 33646775
An antifungal metabolite, designated amphiol (), was isolated from the culture broth of the fungus sp. PF1464. It exists as a mixture of inseparable tautomers, an acetal form and a...
14.
Takenaka K, Kaneko K, Takahashi N, Nishimura S, Kakeya H
Bioorg Med Chem
. 2021 Feb;
35:116059.
PMID: 33611014
α,β-Unsaturated carbonyls are reactive group often found in bioactive small molecules. Their non-specific reaction with biomolecules can be the cause of the low efficacy and unexpected side-effects of the molecule....
15.
Elsadek L, Matthews J, Nishimura S, Nakatani T, Ito A, Gu T, et al.
Chembiochem
. 2021 Feb;
22(10):1790-1799.
PMID: 33527693
Amantelide A, a polyhydroxylated macrolide isolated from a marine cyanobacterium, displays broad-spectrum activity against mammalian cells, bacterial pathogens, and marine fungi. We conducted comprehensive mechanistic studies to identify the molecular...
16.
Ueno R, Nishimura S, Fujimoto G, Ainiwaer D
Curr Med Res Opin
. 2020 Nov;
37(2):253-260.
PMID: 33143482
Objective: To evaluate outcomes, healthcare resource utilization, and costs associated with mucormycosis in inpatient settings in Japan. Methods: We performed a systematic literature review, followed by a retrospective database study...
17.
Kanou A, Nishimura S, Tabuchi T, Matsuyama A, Yoshida M, Kato T, et al.
J Antibiot (Tokyo)
. 2020 Apr;
73(8):574-580.
PMID: 32313168
Serine is an essential component in organisms as a building block of biomolecules, a precursor of metabolites, an allosteric regulator of an enzyme, etc. This amino acid is thought to...
18.
Nishimura S, Matsumori N
Nat Prod Rep
. 2020 Feb;
37(5):677-702.
PMID: 32022056
Covering: up to 2019Nature furnishes bioactive compounds (natural products) with complex chemical structures, yet with simple, sophisticated molecular mechanisms. When natural products exhibit their activities in cells or bodies, they...
19.
Yoshimura A, Nishimura S, Suzuki T, Hattori A, Dohmae N, Kato T, et al.
Org Lett
. 2019 Sep;
21(18):7524-7528.
PMID: 31497968
Myropeptins, novel lipopeptides, were isolated from the culture broth of a fungus F27113. Myropeptin A comprises a linear 20 amino acid-peptide chain and a lauric acid capping the -terminus. Myropeptin...
20.
Sugiyama R, Nakatani T, Nishimura S, Takenaka K, Ozaki T, Asamizu S, et al.
Angew Chem Int Ed Engl
. 2019 Aug;
58(38):13486-13491.
PMID: 31389661
Organisms often produce secondary metabolites as a mixture of biosynthetically related congeners. However, why are metabolites with minor chemical variations produced simultaneously? 5-Alkyl-1,2,3,4-tetrahydroquinolines (5aTHQs) are small, lipophilic metabolites produced by...