Shin-Chen Hou
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Explore the profile of Shin-Chen Hou including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
339
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Recent Articles
1.
Liu Q, Lu Y, Cai C, Huang Y, Zhou L, Guan Y, et al.
Cell Death Dis
. 2024 Jun;
15(6):458.
PMID: 38937437
SARS-CoV-2 infection is initiated by Spike glycoprotein binding to the human angiotensin-converting enzyme 2 (ACE2) receptor via its receptor binding domain. Blocking this interaction has been proven to be an...
2.
Kuo W, Lee C, Chang Y, Pang W, Chen H, Hou S, et al.
J Mol Biol
. 2020 Dec;
433(4):166766.
PMID: 33359099
Interleukin-1β (IL-1β) is a potent pleiotropic cytokine playing a central role in protecting cells from microbial pathogen infection or endogenous stress. After it binds to IL-1RI and recruits IL-1 receptor...
3.
Saxena A, Bai B, Hou S, Jiang L, Ying T, Miersch S, et al.
Methods Mol Biol
. 2018 Sep;
1827:399-417.
PMID: 30196509
The therapeutic efficacy of an antibody drug depends on the variable domains and on the constant crystallizable fragment (Fc). IgG variable domains have been the targets of extensive molecular engineering...
4.
Huang G, Zhong Z, Miersch S, Sidhu S, Hou S, Wu D
J Vis Exp
. 2018 May;
(135).
PMID: 29782009
Demand for monoclonal antibodies (mAbs) in basic research and medicine is increasing yearly. Hybridoma technology has been the dominant method for mAb development since its first report in 1975. As...
5.
Hou S, Chen H, Lin H, Chao W, Chen Y, Fu C, et al.
Sci Rep
. 2016 Aug;
6:31878.
PMID: 27550798
Immunotoxins are an important class of antibody-based therapeutics. The potency of the immunotoxins depends on the antibody fragments as the guiding modules targeting designated molecules on cell surfaces. Phage-displayed synthetic...
6.
Chen H, Hou S, Jian J, Goh K, Shen S, Lee Y, et al.
Sci Rep
. 2015 Jul;
5:12411.
PMID: 26202883
Humoral immunity against diverse pathogens is rapidly elicited from natural antibody repertoires of limited complexity. But the organizing principles underlying the antibody repertoires that facilitate this immunity are not well-understood....
7.
Lin Y, Hou S, Hung C, Lin J, Chen W, Ho C, et al.
Chem Biol Interact
. 2015 Feb;
231:119-26.
PMID: 25643584
The insulin-like growth factor-1 receptor (IGF-1R) plays a pivotal role in transformation, growth, and survival of glioblastoma multiforme (GBM) cells, and has emerged as a general and promising target for...
8.
Chang H, Jian J, Hsu H, Lee Y, Chen H, You J, et al.
Structure
. 2013 Nov;
22(1):9-21.
PMID: 24268648
Protein loops are frequently considered as critical determinants in protein structure and function. Recent advances in high-throughput methods for DNA sequencing and thermal stability measurement have enabled effective exploration of...
9.
Chang H, Hou S, Way T, Wong C, Wang I
Nat Commun
. 2013 Nov;
4:2757.
PMID: 24220679
Conformational disorders are involved in various neurodegenerative diseases. Reactive oxygen species (ROS) are the major contributors to neurodegenerative disease; however, ROS that affect the structural changes in misfolded disease proteins...
10.
Wang I, Chang H, Hou S, Liou G, Way T, Shen C
Nat Commun
. 2012 Apr;
3:766.
PMID: 22473010
The degraded, misfolded C terminus of TAR DNA-binding protein-43 is associated with a wide spectrum of neurodegenerative diseases, particularly frontotemporal lobar degeneration with ubiquitin-positive inclusions and amyotrophic lateral sclerosis. However,...