C-K James Shen
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Explore the profile of C-K James Shen including associated specialties, affiliations and a list of published articles.
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29
Citations
4350
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Recent Articles
1.
Wang J, Hung C, Liou Y, Liu C, Yeh K, Wang K, et al.
Elife
. 2024 May;
12.
PMID: 38752723
A causal relationship exists among the aging process, organ decay and disfunction, and the occurrence of various diseases including cancer. A genetically engineered mouse model, termed or (K74R), carrying mutation...
2.
Park J, Chung C, Park S, Lee D, Kim K, Jeong Y, et al.
Elife
. 2020 Dec;
9.
PMID: 33305734
Cytoplasmic accumulation of TDP-43 in motor neurons is the most prominent pathological feature in amyotrophic lateral sclerosis (ALS). A feedback cycle between nucleocytoplasmic transport (NCT) defect and TDP-43 aggregation was...
3.
Wu L, Cheng W, Chen C, Wu M, Wang Y, Tseng Y, et al.
Acta Neuropathol Commun
. 2019 Mar;
7(1):50.
PMID: 30922385
TAR DNA-binding protein (TDP-43) is a ubiquitously expressed nuclear protein, which participates in a number of cellular processes and has been identified as the major pathological factor in amyotrophic lateral...
4.
Klionsky D, Abdelmohsen K, Abe A, Abedin M, Abeliovich H, Arozena A, et al.
Autophagy
. 2016 Jan;
12(1):1-222.
PMID: 26799652
No abstract available.
5.
Wu P, Lu J, Yang J, Lin I, Ou D, Lin Y, et al.
Cancer Res
. 2014 Dec;
74(24):7333-43.
PMID: 25477335
Aberrant histone methylation is a frequent event during tumor development and progression. KMT1E (also known as SETDB1) is a histone H3K9 methyltransferase that contributes to epigenetic silencing of both oncogenes...
6.
Wu L, Cheng W, Shen C
J Biol Chem
. 2012 Jun;
287(33):27335-44.
PMID: 22718760
ALS, or amyotrophic lateral sclerosis, is a progressive and fatal motor neuron disease with no effective medicine. Importantly, the majority of the ALS cases are with TDP-43 proteinopathies characterized with...
7.
Wang I, Chang H, Hou S, Liou G, Way T, Shen C
Nat Commun
. 2012 Apr;
3:766.
PMID: 22473010
The degraded, misfolded C terminus of TAR DNA-binding protein-43 is associated with a wide spectrum of neurodegenerative diseases, particularly frontotemporal lobar degeneration with ubiquitin-positive inclusions and amyotrophic lateral sclerosis. However,...
8.
Bose J, Huang C, Shen C
J Biol Chem
. 2011 Nov;
286(52):44441-8.
PMID: 22052911
TDP-43 is a DNA/RNA-binding protein with multicellular functions. As a pathosignature protein of a range of neurodegenerative diseases, TDP-43 is also the major component of the polyubiquitinated inclusions in the...
9.
Lin M, Cheng C, Shen C
PLoS One
. 2011 Jun;
6(6):e20371.
PMID: 21673800
Background: TDP-43 is an RNA- and DNA-binding protein well conserved in animals including the mammals, Drosophila, and C. elegans. In mammals, the multi-function TDP-43 encoded by the TARDBP gene is...
10.
Chen R, Chou Y, Lan Y, Huang T, Shen C
J Biol Chem
. 2010 Feb;
285(14):10189-97.
PMID: 20133935
The mammalian embryonic zeta-globin genes, including that of humans, are expressed at the early embryonic stage and then switched off during erythroid development. This autonomous silencing of the zeta-globin gene...