Shih-Hsing Leir
Overview
Explore the profile of Shih-Hsing Leir including associated specialties, affiliations and a list of published articles.
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57
Citations
972
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Recent Articles
1.
Leir S, Tkachenko S, Paranjapye A, Meckler F, Van Wettere A, Kerschner J, et al.
Mol Med
. 2024 Aug;
30(1):115.
PMID: 39112965
Background: Pancreatic fibrosis is an early diagnostic feature of the common inherited disorder cystic fibrosis (CF). Many people with CF (pwCF) are pancreatic insufficient from birth and the replacement of...
2.
Coatti G, Vaghela N, Gillurkar P, Leir S, Harris A
Biochim Biophys Acta Gene Regul Mech
. 2024 Apr;
1867(2):195031.
PMID: 38679287
The cystic fibrosis transmembrane conductance regulator (CFTR) gene encodes an anion-selective channel found in epithelial cell membranes. Mutations in CFTR cause cystic fibrosis (CF), an inherited disorder that impairs epithelial...
3.
Leir S, Paranjapye A, Harris A
Andrology
. 2023 Jun;
12(5):991-1000.
PMID: 37301539
Background: The human epididymis is poorly studied due to the lack of availability of tissue samples. Our understanding of its structure and function depends upon anatomical and histological observations of...
4.
Kerschner J, Paranjapye A, Schacht M, Meckler F, Huang F, Bebek G, et al.
Funct Integr Genomics
. 2023 Apr;
23(2):135.
PMID: 37085733
The precise molecular events initiating human lung disease are often poorly characterized. Investigating prenatal events that may underlie lung disease in later life is challenging in man, but insights from...
5.
Van Wettere A, Leir S, Cotton C, Regouski M, Viotti Perisse I, Kerschner J, et al.
FASEB Bioadv
. 2023 Jan;
5(1):13-26.
PMID: 36643895
Highly effective modulator therapies for cystic fibrosis (CF) make it a treatable condition for many people. However, although CF respiratory illness occurs after birth, other organ systems particularly in the...
6.
Burkhanova U, Harris A, Leir S
Stem Cell Res
. 2022 Nov;
65:102967.
PMID: 36395690
Cross-talk between lung epithelial cells and their microenvironment has an important physiological role in development. Using an in vitro model of differentiation of human induced pluripotent stem cells (iPSCs) to...
7.
Paranjapye A, Leir S, Huang F, Kerschner J, Harris A
Eur J Cell Biol
. 2022 May;
101(3):151231.
PMID: 35597096
The evolutionary relationship of cells within tissues having a similar function but located in different anatomical sites is of considerable biological interest. The development of single-cell RNA sequencing (scRNA-seq) protocols...
8.
Viotti Perisse I, Fan Z, van Wettere A, Liu Y, Leir S, Keim J, et al.
FASEB Bioadv
. 2021 Oct;
3(10):841-854.
PMID: 34632318
Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator () gene. The F508del and G542X are the most common mutations found in US...
9.
Nandymazumdar M, Paranjapye A, Browne J, Yin S, Leir S, Harris A
Biochem J
. 2021 Oct;
478(20):3741-3756.
PMID: 34605540
The cystic fibrosis transmembrane conductance regulator (CFTR) gene lies within a topologically associated domain (TAD) in which multiple cis-regulatory elements (CREs) and transcription factors (TFs) regulate its cell-specific expression. The...
10.
Paranjapye A, Nandymazumdar M, Browne J, Leir S, Harris A
J Biol Chem
. 2021 Jul;
297(2):100932.
PMID: 34217701
A complex network of transcription factors regulates genes involved in establishing and maintaining key biological properties of the human airway epithelium. However, detailed knowledge of the contributing factors is incomplete....