Michael J Mutolo
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Explore the profile of Michael J Mutolo including associated specialties, affiliations and a list of published articles.
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10
Citations
185
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Recent Articles
1.
The FOXA1 transcriptional network coordinates key functions of primary human airway epithelial cells
Paranjapye A, Mutolo M, Ebron J, Leir S, Harris A
Am J Physiol Lung Cell Mol Physiol
. 2020 May;
319(1):L126-L136.
PMID: 32432922
The differentiated functions of the human airway epithelium are coordinated by a complex network of transcription factors. These include the pioneer factors Forkhead box A1 and A2 (FOXA1 and FOXA2),...
2.
Gawenis L, Hodges C, McHugh D, Valerio D, Miron A, Cotton C, et al.
Sci Rep
. 2019 Aug;
9(1):11828.
PMID: 31413336
Small-molecule modulators of cystic fibrosis transmembrane conductance regulator (CFTR) biology show promise in the treatment of cystic fibrosis (CF). A Cftr knockout (Cftr KO) mouse expressing mutants of human CFTR...
3.
Mutolo M, Leir S, Fossum S, Browne J, Harris A
Biochem J
. 2018 Mar;
475(7):1323-1334.
PMID: 29572268
Mutations in the cystic fibrosis transmembrane conductance regulator () gene cause the inherited disorder cystic fibrosis (CF). Lung disease is the major cause of CF morbidity, though expression levels are...
4.
Fossum S, Mutolo M, Tugores A, Ghosh S, Randell S, Jones L, et al.
J Biol Chem
. 2017 May;
292(26):10938-10949.
PMID: 28461336
The airway epithelium forms a barrier between the internal and external environments. Epithelial dysfunction is critical in the pathology of many respiratory diseases, including cystic fibrosis. Ets homologous factor (EHF)...
5.
Cai Z, Palmai-Pallag T, Khuituan P, Mutolo M, Boinot C, Liu B, et al.
J Physiol
. 2015 Mar;
593(11):2427-46.
PMID: 25763566
Key Points: Malfunction of the cystic fibrosis transmembrane conductance regulator (CFTR), a gated pathway for chloride movement, causes the common life-shortening genetic disease cystic fibrosis (CF). Towards the development of...
6.
Fossum S, Mutolo M, Yang R, Dang H, ONeal W, Knowles M, et al.
Nucleic Acids Res
. 2014 Nov;
42(22):13588-98.
PMID: 25414352
Ets homologous factor (EHF) is an Ets family transcription factor expressed in many epithelial cell types including those lining the respiratory system. Disruption of the airway epithelium is central to...
7.
Clementz A, Mutolo M, Leir S, Morris K, Kucybala K, Harris H, et al.
PLoS One
. 2013 Aug;
8(8):e72250.
PMID: 23991074
Collagen XV (COLXV) is a secreted non-fibrillar collagen found within basement membrane (BM) zones of the extracellular matrix (ECM). Its ability to alter cellular growth in vitro and to reduce...
8.
Mutolo M, Morris K, Leir S, Caffrey T, Lewandowska M, Hollingsworth M, et al.
Matrix Biol
. 2012 Apr;
31(5):285-9.
PMID: 22531369
Non-fibrillar collagen XV is a chondroitin sulfate modified glycoprotein that is associated with the basement membrane zone in many tissues. Its precise functions remain to be fully elucidated though it...
9.
Mutolo M, Jenny L, Buszek A, Fenton T, Foran D
Am J Phys Anthropol
. 2012 Jan;
147(2):254-63.
PMID: 22212927
Ancient skeletal remains can harbor unique information about past civilizations at both the morphological and molecular levels. For instance, a number of diseases manifest in bone, some of which have...
10.
Dunham P, Kelley S, Logue P, Mutolo M, Milanick M
Am J Physiol Cell Physiol
. 2005 Mar;
289(2):C277-82.
PMID: 15772122
Amiloride-inhibitable Li+ influx in dog red blood cells is mediated by the Na+/H+ exchanger, NHE. However, there are substantial differences between the properties of Li+ transport and Na+ transport through...