Jenny L Kerschner
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Explore the profile of Jenny L Kerschner including associated specialties, affiliations and a list of published articles.
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29
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514
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Recent Articles
1.
Leir S, Tkachenko S, Paranjapye A, Meckler F, Van Wettere A, Kerschner J, et al.
Mol Med
. 2024 Aug;
30(1):115.
PMID: 39112965
Background: Pancreatic fibrosis is an early diagnostic feature of the common inherited disorder cystic fibrosis (CF). Many people with CF (pwCF) are pancreatic insufficient from birth and the replacement of...
2.
Vaidyanathan S, Kerschner J, Paranjapye A, Sinha V, Lin B, Bedrosian T, et al.
Mol Ther Nucleic Acids
. 2024 Feb;
35(1):102134.
PMID: 38384445
A "universal strategy" replacing the full-length cDNA may treat >99% of people with cystic fibrosis (pwCF), regardless of their specific mutations. Cas9-based gene editing was used to insert the cDNA...
3.
Kerschner J, Meckler F, Coatti G, Vaghela N, Paranjapye A, Harris A
J Cell Mol Med
. 2024 Feb;
28(4):e18142.
PMID: 38372567
We identified and characterized multiple cell-type selective enhancers of the CFTR gene promoter in previous work and demonstrated active looping of these elements to the promoter. Here we address the...
4.
Kerschner J, Paranjapye A, Harris A
Physiol Rep
. 2023 Jun;
11(11):e15700.
PMID: 37269165
The airway epithelial cell line, 16HBE14o , is an important cell model for studying airway disease. 16HBE14o cells were originally generated from primary human bronchial epithelial cells by SV40-mediated immortalization,...
5.
Kerschner J, Paranjapye A, Schacht M, Meckler F, Huang F, Bebek G, et al.
Funct Integr Genomics
. 2023 Apr;
23(2):135.
PMID: 37085733
The precise molecular events initiating human lung disease are often poorly characterized. Investigating prenatal events that may underlie lung disease in later life is challenging in man, but insights from...
6.
Van Wettere A, Leir S, Cotton C, Regouski M, Viotti Perisse I, Kerschner J, et al.
FASEB Bioadv
. 2023 Jan;
5(1):13-26.
PMID: 36643895
Highly effective modulator therapies for cystic fibrosis (CF) make it a treatable condition for many people. However, although CF respiratory illness occurs after birth, other organ systems particularly in the...
7.
Kerschner J, Paranjapye A, Vaghela N, Wilson M, Harris A
Gene Ther
. 2022 Dec;
30(6):478-486.
PMID: 36510002
Transcription of the cystic fibrosis transmembrane conductance regulator (CFTR) gene is regulated by both ubiquitous and cell-type selective cis-regulatory elements (CREs). These CREs include extragenic and intronic enhancers that bind...
8.
Paranjapye A, Leir S, Huang F, Kerschner J, Harris A
Eur J Cell Biol
. 2022 May;
101(3):151231.
PMID: 35597096
The evolutionary relationship of cells within tissues having a similar function but located in different anatomical sites is of considerable biological interest. The development of single-cell RNA sequencing (scRNA-seq) protocols...
9.
Kerschner J, Paranjapye A, Nandymazumdar M, Yin S, Leir S, Harris A
Dev Dyn
. 2021 Jan;
250(5):684-700.
PMID: 33386644
Background: Cell-specific and developmental mechanisms contribute to expression of the cystic fibrosis transmembrane conductance regulator (CFTR) gene; however, its developmental regulation is poorly understood. Here we use human induced pluripotent...
10.
Leir S, Yin S, Kerschner J, Cosme W, Harris A
Life Sci Alliance
. 2020 Aug;
3(11).
PMID: 32855272
Spermatozoa released from the testis are unable to fertilize an egg without a coordinated process of maturation in the lumen of the epididymis. Relatively little is known about the molecular...