Shigeru Hoshiko
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Explore the profile of Shigeru Hoshiko including associated specialties, affiliations and a list of published articles.
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12
Citations
85
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Recent Articles
1.
Takahata S, Iida M, Yoshida T, Kumura K, Kitagawa H, Hoshiko S
J Antibiot (Tokyo)
. 2007 Apr;
60(2):123-8.
PMID: 17420562
4-Pyridone derivatives were identified as potent inhibitors of FabI, the enoyl-acyl carrier protein reductase in Escherichia coli and Staphylococcus aureus. 1-Substituted derivatives of a hit compound exhibited potent antibacterial activities...
2.
Takahata S, Ida T, Senju N, Sanbongi Y, Miyata A, Maebashi K, et al.
Antimicrob Agents Chemother
. 2007 Feb;
51(5):1589-95.
PMID: 17325223
Horizontal gene transfer has been identified in only a small number of genes in Haemophilus influenzae, an organism which is naturally competent for transformation. This report provides evidence for the...
3.
Takahata S, Iida M, Osaki Y, Saito J, Kitagawa H, Ozawa T, et al.
Antimicrob Agents Chemother
. 2006 Jul;
50(8):2869-71.
PMID: 16870790
AG205 was identified from high-throughput screening as a potent inhibitor of FabK, the enoyl-ACP reductase in Streptococcus pneumoniae. Specific inhibition of lipid biosynthesis in a macromolecular biosynthesis assay and identification...
4.
Shinei R, Kurihara K, Tanabe K, Tabata Y, Kurata Y, Hoshiko S, et al.
Bioorg Med Chem
. 2006 Apr;
14(14):4850-61.
PMID: 16580213
We have synthesized a series of nonsteroidal progesterone receptor (PR) ligands, tetrahydronaphthofuranones, structurally based on the fungal metabolite PF1092C. Structure-activity relationship studies revealed that substituents at the 6- and 7-positions...
5.
Kurihara K, Shinei R, Tanabe K, Tabata Y, Kurata Y, Hoshiko S, et al.
Bioorg Med Chem
. 2006 Apr;
14(14):4862-78.
PMID: 16580209
The human progesterone receptor (PR) binding affinity and the PR agonistic or antagonistic potency of tetrahydronaphthofuranone derivatives were shown previously to be markedly influenced by substituents at the 6- and...
6.
Takahata S, Okutomi T, Ohtsuka K, Hoshiko S, Uchida K, Yamaguchi H
Med Mycol
. 2005 Jul;
43(3):227-33.
PMID: 16010849
To evaluate the therapeutic potential of FX0685, a new triazole antifungal agent, for the treatment of opportunistic fungal infections, particularly systemic candidiasis and aspergillosis, in vitro and in vivo studies...
7.
Kurata Y, Tabata Y, Shinei R, Iizuka Y, Masuda N, Kurihara K, et al.
J Pharmacol Exp Ther
. 2005 Mar;
313(2):916-20.
PMID: 15743919
We have isolated PF1092A, B, and C, novel nonsteroidal progesterone ligands with preferential affinity for the progesterone receptor, from fermentation broth of a fungus [Tabata Y, Miike N, Hatsu M,...
8.
Nakajima H, Nagaso H, Kakui N, Ishikawa M, Hiranuma T, Hoshiko S
J Biol Chem
. 2004 Aug;
279(41):42774-86.
PMID: 15302869
Synthesis of ADP-ribose polymers catalyzed by poly-(ADP-ribose) polymerase-1 (PARP-1) has been implicated in transcriptional regulation. Recent studies with PARP-1 null mice and PARP-1 inhibitors have also demonstrated that PARP-1 has...
9.
Tabata Y, Iizuka Y, Shinei R, Kurihara K, Okonogi T, Hoshiko S, et al.
Eur J Pharmacol
. 2003 Feb;
461(1):73-8.
PMID: 12568918
We investigated progestational activity of a new nonsteroidal compound, CP8668, ((4aR,5R,6R,7R)-7-methoxy-6-(N-propylaminocarbonyl)oxy-4a,5,6,7-tetrahydro-1,3,4a,5-tetramethylbenz[f]indol-2(4H)-one). CP8668 showed selective affinity for human progesterone receptor equal in strength to other steroidal progestins. CP8668 showed no significant...
10.
Nose H, Fushimi H, Seki A, Sasaki T, Watabe H, Hoshiko S
J Antibiot (Tokyo)
. 2003 Jan;
55(11):969-74.
PMID: 12546418
PF1163A and B are a pair of antifungal agents isolated from a fermentation broth of Penicillium sp. PF1163A inhibited ergosterol synthesis in Saccharomyces cerevisiae, resulting in an accumulation of 4,4-dimethylzymosterol...