Sherwin Kelekar
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Explore the profile of Sherwin Kelekar including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
98
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Recent Articles
1.
Bezwada D, Perelli L, Lesner N, Cai L, Brooks B, Wu Z, et al.
Nature
. 2024 Aug;
633(8031):923-931.
PMID: 39143213
Most kidney cancers are metabolically dysfunctional, but how this dysfunction affects cancer progression in humans is unknown. We infused C-labelled nutrients in over 80 patients with kidney cancer during surgical...
2.
Wu Z, Bezwada D, Cai F, Harris R, Ko B, Sondhi V, et al.
Cell Metab
. 2024 Jun;
36(7):1504-1520.e9.
PMID: 38876105
Mitochondria house many metabolic pathways required for homeostasis and growth. To explore how human cells respond to mitochondrial dysfunction, we performed metabolomics in fibroblasts from patients with various mitochondrial disorders...
3.
Wang X, Menezes C, Jia Y, Xiao Y, Venigalla S, Cai F, et al.
Science
. 2024 Jun;
384(6701):eadj4301.
PMID: 38870309
Mitochondria are critical for proper organ function and mechanisms to promote mitochondrial health during regeneration would benefit tissue homeostasis. We report that during liver regeneration, proliferation is suppressed in electron...
4.
Cai F, Bezwada D, Cai L, Mahar R, Wu Z, Chang M, et al.
Cell Metab
. 2023 Aug;
35(10):1830-1843.e5.
PMID: 37611583
Stable isotopes are powerful tools to assess metabolism. C labeling is detected using nuclear magnetic resonance (NMR) spectroscopy or mass spectrometry (MS). MS has excellent sensitivity but generally cannot discriminate...
5.
Wu Z, Bezwada D, Harris R, Pan C, Nguyen P, Faubert B, et al.
bioRxiv
. 2023 May;
PMID: 37214913
Cancer cells reprogram their metabolism to support cell growth and proliferation in harsh environments. While many studies have documented the importance of mitochondrial oxidative phosphorylation (OXPHOS) in tumor growth, some...
6.
Bezwada D, Lesner N, Brooks B, Vu H, Wu Z, Cai L, et al.
bioRxiv
. 2023 Feb;
PMID: 36798172
Most kidney cancers display evidence of metabolic dysfunction but how this relates to cancer progression in humans is unknown. We used a multidisciplinary approach to infuse C-labeled nutrients during surgical...
7.
Soflaee M, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, et al.
Nat Commun
. 2022 May;
13(1):2698.
PMID: 35577785
Purine nucleotides are necessary for various biological processes related to cell proliferation. Despite their importance in DNA and RNA synthesis, cellular signaling, and energy-dependent reactions, the impact of changes in...
8.
Solmonson A, Faubert B, Gu W, Rao A, Cowdin M, Menendez-Montes I, et al.
Nature
. 2022 Apr;
604(7905):349-353.
PMID: 35388219
Mammalian embryogenesis requires rapid growth and proper metabolic regulation. Midgestation features increasing oxygen and nutrient availability concomitant with fetal organ development. Understanding how metabolism supports development requires approaches to observe...
9.
Sun S, Kelekar S, Kliewer S, Mangelsdorf D
Genes Dev
. 2019 Jul;
33(15-16):1083-1094.
PMID: 31296559
The orphan nuclear receptor SHP (small heterodimer partner) is a well-known transcriptional corepressor of bile acid and lipid metabolism in the liver; however, its function in other tissues is poorly...