Shengyun Fang
Overview
Explore the profile of Shengyun Fang including associated specialties, affiliations and a list of published articles.
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Articles
78
Citations
7678
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Recent Articles
1.
Xiao H, Li M, Zhong Y, Patel A, Xu R, Zhang C, et al.
FASEB J
. 2025 Jan;
39(1):e70283.
PMID: 39760245
Molecular chaperones play critical roles in post-translational maintenance in protein homeostasis. Previous studies have shown that loss of Smyd1b function results in defective myofibril organization and dramatic upregulation of heat...
2.
Xu R, Li S, Chien C, Zhong Y, Xiao H, Fang S, et al.
Mol Cell Biol
. 2024 Sep;
44(12):543-561.
PMID: 39320962
Smyd1, a member of the Smyd lysine methyltransferase family, plays an important role in myofibrillogenesis of skeletal and cardiac muscles. Loss of Smyd1b (a Smyd1 ortholog) function in zebrafish results...
3.
Liu Y, Gu Y, Chen Y, Wang X, Zhou G, Li J, et al.
Cell Rep
. 2024 Jun;
43(7):114402.
PMID: 38943644
The unfolded protein response (UPR) relieves endoplasmic reticulum (ER) stress through multiple strategies, including reducing protein synthesis, increasing protein folding capabilities, and enhancing misfolded protein degradation. After a multi-omics analysis,...
4.
Yan W, Zhong Y, Hu X, Xu T, Zhang Y, Kales S, et al.
Nat Commun
. 2023 Aug;
14(1):4798.
PMID: 37558718
UBA1 is the primary E1 ubiquitin-activating enzyme responsible for generation of activated ubiquitin required for ubiquitination, a process that regulates stability and function of numerous proteins. Decreased or insufficient ubiquitination...
5.
Chen X, Hu X, Jiang J, Tao J, Liu L, Fang S, et al.
Genes Dis
. 2023 May;
10(2):366-369.
PMID: 37223506
No abstract available.
6.
Ruan J, Liang D, Yan W, Zhong Y, Talley D, Rai G, et al.
Mol Biol Cell
. 2022 Sep;
33(13):ar120.
PMID: 36074076
RNF5 E3 ubiquitin ligase has multiple biological roles and has been linked to the development of severe diseases such as cystic fibrosis, acute myeloid leukemia, and certain viral infections, emphasizing...
7.
Deshmukh D, Xu J, Yang X, Shimelis H, Fang S, Qiu Y
Pharmaceutics
. 2022 Apr;
14(4).
PMID: 35456636
The cyclin-dependent kinase inhibitor p27 (Kip1) is an important regulator of the G1/S checkpoint. It is degraded by the SCF-SKP2 complex in late G1 thereby allowing cells to progress to...
8.
Zhong Y, Yan W, Ruan J, Fang M, Yu C, Du S, et al.
Hum Mol Genet
. 2022 Mar;
31(15):2639-2654.
PMID: 35333353
XBP1 variant 1 (Xv1) is the most abundant XBP1 variant and is highly enriched across cancer types but nearly none in normal tissues. Its expression is associated with poor patients'...
9.
Zhong Y, Yan W, Ruan J, Fang M, Lapidus R, Du S, et al.
Biochem Biophys Res Commun
. 2021 May;
562:69-75.
PMID: 34038755
XBP1 is a basic leucine zipper (bZIP) transcription factor and a key mediator of the endoplasmic reticulum (ER) stress-activated unfolded protein response (UPR). XBP1-mediated transcription facilitates cell adaptation to ER...
10.
Xu J, Yang X, Deshmukh D, Chen H, Fang S, Qiu Y
Cells
. 2020 May;
9(5).
PMID: 32354165
Background: Drug resistance is one of the most prevalent causes of death in advanced prostate cancer patients. Combination therapies that target cancer cells via different mechanisms to overcome resistance have...