Shengtao Xu
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Explore the profile of Shengtao Xu including associated specialties, affiliations and a list of published articles.
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118
Citations
943
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Recent Articles
1.
Guo X, Xu S, Gu R, Zhang D, Gong S, Xu J, et al.
Angew Chem Int Ed Engl
. 2025 Jan;
:e202414613.
PMID: 39887810
Insufficient ionic conductivity and elevated desolvation energy barrier of electrolytes limit the low-temperature applications of lithium metal batteries (LMBs). Weakly solvating electrolytes (WSEs), with limited lithium salt dissociation capability, are...
2.
Xie S, Zhu J, Peng Y, Zhan F, Zhan F, He C, et al.
Angew Chem Int Ed Engl
. 2024 Dec;
64(11):e202421713.
PMID: 39714400
Proteolysis targeting chimeras (PROTACs) hold immense promise for targeted protein degradation; however, challenges such as off-target effects, poor drug-likeness properties, and the "hook effect" remain. This study introduces Nano-Click-formed PROTACs...
3.
Li W, Wang K, Wang P, Yang P, Xu S, Tong J, et al.
J Hazard Mater
. 2024 Nov;
483():136626.
PMID: 39603119
This study investigated the impact of glyphosate on bacterial communities and their degradation mechanisms in large-leaf tea soil, through exposure microcosm and enrichment culture experiments. Soils from three tea gardens...
4.
Duan Y, Guo Z, Zhong W, Chen J, Xu S, Liu J, et al.
Future Med Chem
. 2024 Nov;
16(22):2431-2450.
PMID: 39582317
Hematopoietic progenitor kinase 1 (HPK1) is a serine-threonine kinase specific to hematopoiesis and a member of the MAP4K family of Ste20-related protein kinases. Targeting HPK1 to ameliorate T cell exhaustion...
5.
Li J, Zhang T, Wu D, He C, Weng H, Zheng T, et al.
J Med Chem
. 2024 Nov;
67(21):19905-19924.
PMID: 39484713
Bioorthogonal cleavage reactions have been developed as an intriguing strategy to enhance the safety of chemotherapeutics. Aiming to reduce the toxicity and improve the targeted release properties of the colchicine...
6.
Chen L, Zhang B, Zhou P, Duan Y, He C, Zhong W, et al.
Bioorg Chem
. 2024 Sep;
153:107814.
PMID: 39299176
Hematopoietic progenitor kinase 1 (HPK1), a negative regulator of T cell receptor signaling, plays a crucial role in multiple cellular immune responses. Emerging researches have demonstrated that inhibiting HPK1 kinase...
7.
Guo Q, Zhou Y, Ni H, Niu M, Xu S, Zheng L, et al.
J Transl Med
. 2024 Sep;
22(1):832.
PMID: 39256760
Background: The roles of the transcriptional factor SIX2 have been identified in several tumors. However, its roles in gastric cancer (GC) progression have not yet been revealed. Our objective is...
8.
Wang P, Zhu H, Tian J, Zhu W, Xu S, Yao H, et al.
J Med Chem
. 2024 Jul;
67(18):16128-16144.
PMID: 38968440
Herein, a series of novel arylpiperazine (piperidine) derivatives were designed, synthesized, and evaluated for mechanisms of action through and studies. The most promising compound, (later named as ), is a...
9.
Guo Z, Duan Y, Sun K, Zheng T, Liu J, Xu S, et al.
Eur J Med Chem
. 2024 Jun;
275:116579.
PMID: 38889611
SHP2 is a non-receptor tyrosine phosphatase encoded by PTPN11, which performs the functions of regulating cell proliferation, differentiation, apoptosis, and survival through removing tyrosine phosphorylation and modulating various signaling pathways....
10.
He C, Liu J, Li J, Wu H, Jiao C, Ze X, et al.
J Med Chem
. 2024 May;
67(11):9406-9430.
PMID: 38751194
Targeting NLRP3 inflammasome with inhibitors is a novel strategy for NLRP3-driven diseases. Herein, hit compound possessing an attractive skeleton was identified from our in-house database of oridonin, and then a...