Shayne A Bellingham
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Explore the profile of Shayne A Bellingham including associated specialties, affiliations and a list of published articles.
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23
Citations
1047
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Recent Articles
1.
Cheng L, Quek C, Li X, Bellingham S, Ellett L, Shambrook M, et al.
Commun Biol
. 2021 Mar;
4(1):411.
PMID: 33767334
Prion diseases are distinguished by long pre-clinical incubation periods during which prions actively propagate in the brain and cause neurodegeneration. In the pre-clinical stage, we hypothesize that upon prion infection,...
2.
Easteal S, Arkell R, Balboa R, Bellingham S, Brown A, Calma T, et al.
Am J Hum Genet
. 2020 Aug;
107(2):175-182.
PMID: 32763188
Expanded carrier screening (ECS) for recessive monogenic diseases requires prior knowledge of genomic variation, including DNA variants that cause disease. The composition of pathogenic variants differs greatly among human populations,...
3.
Zhao W, Cheng L, Quek C, Bellingham S, Hill A
Sci Rep
. 2019 Nov;
9(1):17449.
PMID: 31767948
MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene or protein expression by targeting mRNAs and triggering either translational repression or mRNA degradation. Distinct expression levels of...
4.
Bellingham S, Hill A
Methods Mol Biol
. 2017 Sep;
1658:67-80.
PMID: 28861783
Prion diseases or transmissible spongiform encephalopathies are disorders of the central nervous system that affect both humans and animals. The underlying cause of prion diseases is the formation and propagation...
5.
Quek C, Bellingham S, Jung C, Scicluna B, Shambrook M, Sharples R, et al.
RNA Biol
. 2016 Dec;
14(2):245-258.
PMID: 28005467
Small non-coding RNAs (ncRNA), including microRNAs (miRNA), enclosed in exosomes are being utilised for biomarker discovery in disease. Two common exosome isolation methods involve differential ultracentrifugation or differential ultracentrifugation coupled...
6.
Bellingham S, Shambrook M, Hill A
Methods Mol Biol
. 2016 Dec;
1545:55-70.
PMID: 27943207
Extracellular vesicles, such as exosomes and microvesicles, have been shown to contain potential microRNA (miRNA) biomarkers that may be utilized in the diagnosis of various diseases from cancer to neurological...
7.
Guo B, Bellingham S, Hill A
J Biol Chem
. 2016 Jan;
291(10):5128-37.
PMID: 26769968
Exosomes are small extracellular vesicles released by cells and play important roles in intercellular communication and pathogen transfer. Exosomes have been implicated in several neurodegenerative diseases, including prion disease and...
8.
Quek C, Jung C, Bellingham S, Lonie A, Hill A
J Extracell Vesicles
. 2015 Nov;
4:29454.
PMID: 26561006
Small non-coding RNAs have been significantly recognized as the key modulators in many biological processes, and are emerging as promising biomarkers for several diseases. These RNA species are transcribed in...
9.
Bellingham S, Guo B, Hill A
Biol Cell
. 2015 Jun;
107(11):389-418.
PMID: 26032945
Biologically active metals such as copper, zinc and iron are fundamental for sustaining life in different organisms with the regulation of cellular metal homeostasis tightly controlled through proteins that coordinate...
10.
Guo B, Bellingham S, Hill A
J Biol Chem
. 2014 Dec;
290(6):3455-67.
PMID: 25505180
Prion diseases are a group of transmissible, fatal neurodegenerative disorders associated with the misfolding of the host-encoded prion protein, PrP(C), into a disease-associated form, PrP(Sc). The transmissible prion agent is...