Giuseppe D Ciccotosto
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Explore the profile of Giuseppe D Ciccotosto including associated specialties, affiliations and a list of published articles.
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56
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2070
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Recent Articles
1.
Butler C, Ciccotosto G, Rygh N, Bijlsma E, Dashper S, Brown A
J Infect Dis
. 2024 Sep;
230(Supplement_2):S87-S94.
PMID: 39255395
Periodontitis is a common chronic inflammatory disease, affecting approximately 19% of the global adult population. A relationship between periodontal disease and Alzheimer disease has long been recognized, and recent evidence...
2.
Ciccotosto G, Mohammed A, Paolini R, Bijlsma E, Toulson S, Holden J, et al.
J Infect Dis
. 2024 Sep;
230(Supplement_2):S109-S116.
PMID: 39255392
Periodontitis is a chronic inflammatory disease driven by dysbiosis in subgingival microbial communities leading to increased abundance of a limited number of pathobionts, including Porphyromonas gingivalis and Treponema denticola. Oral...
3.
Ameen S, Griem-Krey N, Dufour A, Hossain M, Hoque A, Sturgeon S, et al.
Mol Cell Proteomics
. 2023 Apr;
22(5):100543.
PMID: 37030595
Excitotoxicity, a neuronal death process in neurological disorders such as stroke, is initiated by the overstimulation of ionotropic glutamate receptors. Although dysregulation of proteolytic signaling networks is critical for excitotoxicity,...
4.
Luu L, Ciccotosto G, Cappai R
Curr Alzheimer Res
. 2021 Dec;
18(10):772-786.
PMID: 34879801
The Amyloid Precursor Protein (APP) is principally known and studied for its involvement in Alzheimer's disease as the source of the amyloid β peptide; however, its physiological actions within the...
5.
Truong P, Crouch P, Hilton J, McLean C, Cappai R, Ciccotosto G
Cell Mol Life Sci
. 2021 Sep;
78(19-20):6605-6630.
PMID: 34476545
Motor neurone disease (MND) is a neurodegenerative disorder characterised by progressive destruction of motor neurons, muscle paralysis and death. The amyloid precursor protein (APP) is highly expressed in the central...
6.
Inampudi C, Ciccotosto G, Cappai R, Crack P
J Neurotrauma
. 2020 Feb;
37(5):706-723.
PMID: 32027210
Traumatic brain injury (TBI) is a major health problem causing disability and death worldwide. There is no effective treatment, due in part to the complexity of the injury pathology and...
7.
Hoque A, Williamson N, Ameen S, Ciccotosto G, Hossain M, Oakhill J, et al.
Cell Death Dis
. 2019 Mar;
10(3):213.
PMID: 30824683
Excitotoxicity, caused by overstimulation or dysregulation of ionotropic glutamate receptors (iGluRs), is a pathological process directing neuronal death in many neurological disorders. The aberrantly stimulated iGluRs direct massive influx of...
8.
Truong P, Ciccotosto G, Merson T, Spoerri L, Chuei M, Ayers M, et al.
Glia
. 2018 Dec;
67(3):525-538.
PMID: 30506868
The identification of factors that regulate myelination provides important insight into the molecular mechanisms that coordinate nervous system development and myelin regeneration after injury. In this study, we investigated the...
9.
Dai C, Xiao X, Li J, Ciccotosto G, Cappai R, Tang S, et al.
ACS Chem Neurosci
. 2018 Oct;
10(1):120-131.
PMID: 30362702
Neurotoxicity is one major unwanted side-effects associated with polymyxin (i.e., colistin and polymyxin B) therapy. Clinically, colistin neurotoxicity is characterized by neurological symptoms including dizziness, visual disturbances, vertigo, confusion, hallucinations,...
10.
Truong P, Ciccotosto G, Cappai R
Neurochem Res
. 2018 Oct;
44(6):1356-1366.
PMID: 30362021
The amyloid precursor protein (APP) is a member of a conserved gene family that includes the amyloid precursor-like proteins 1 (APLP1) and 2 (APLP2). APP and APLP2 share a high...