Shawn P Williams
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Explore the profile of Shawn P Williams including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
964
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Recent Articles
1.
Barton L, Callahan J, Cantizani J, Concha N, Cotillo Torrejon I, Goodwin N, et al.
Bioorg Med Chem
. 2024 Feb;
100:117618.
PMID: 38309201
The virally encoded 3C-like protease (3CL) is a well-validated drug target for the inhibition of coronaviruses including Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Most inhibitors of 3CL are peptidomimetic, with...
2.
Ramanjulu J, Williams S, Lakdawala A, DeMartino M, Lan Y, Marquis R
ACS Med Chem Lett
. 2021 Sep;
12(9):1396-1404.
PMID: 34531948
The pregnane X receptor (PXR) regulates expression of proteins responsible for all three phases required for the detoxification mechanism, which include CYP450 enzymes, phase II enzymes, and multidrug efflux pumps....
3.
Price D, Drewry D, Schaller L, Thompson B, Reid P, Maloney P, et al.
Bioorg Med Chem Lett
. 2018 Apr;
28(10):1958-1963.
PMID: 29653895
Hypothalamic CAMKK2 represents a potential mechanism for chemically affecting satiety and promoting weight loss in clinically obese patients. Single-digit nanomolar inhibitors of CAMKK2 were identified in three related ATP-competitive series....
4.
Williams S, Beckerman B, Pina Fonti M
J Chiropr Med
. 2015 Feb;
13(2):144-8.
PMID: 25685125
Objective: The purpose of this case report is to describe the presentation of a patient with lumbosacral chordoma characterized by somatic chronic low back pain and intermittent sacral nerve impingement....
5.
Hardwicke M, Rendina A, Williams S, Moore M, Wang L, Krueger J, et al.
Nat Chem Biol
. 2014 Aug;
10(9):774-9.
PMID: 25086508
Human fatty acid synthase (hFAS) is a complex, multifunctional enzyme that is solely responsible for the de novo synthesis of long chain fatty acids. hFAS is highly expressed in a...
6.
Williams S, Zipp G
J Manipulative Physiol Ther
. 2014 Jan;
37(3):180-9.
PMID: 24387887
Objective: The purpose of this study was to establish the frequency of burnout among doctors of chiropractic in the United States. Methods: Using a nonprobability convenience sampling methodology, we e-mailed...
7.
Akwabi-Ameyaw A, Caravella J, Chen L, Creech K, Deaton D, Madauss K, et al.
Bioorg Med Chem Lett
. 2011 Sep;
21(20):6154-60.
PMID: 21890356
To further explore the optimum placement of the acid moiety in conformationally constrained analogs of GW 4064 1a, a series of stilbene replacements were prepared. The benzothiophene 1f and the...
8.
Whitby R, Stec J, Blind R, Dixon S, Leesnitzer L, Orband-Miller L, et al.
J Med Chem
. 2011 Mar;
54(7):2266-81.
PMID: 21391689
The crystal structure of LRH-1 ligand binding domain bound to our previously reported agonist 3-(E-oct-4-en-4-yl)-1-phenylamino-2-phenyl-cis-bicyclo[3.3.0]oct-2-ene 5 is described. Two new classes of agonists in which the bridgehead anilino group from...
9.
Bass J, Caravella J, Chen L, Creech K, Deaton D, Madauss K, et al.
Bioorg Med Chem Lett
. 2011 Jan;
21(4):1206-13.
PMID: 21256005
To improve on the drug properties of GSK8062 1b, a series of heteroaryl bicyclic naphthalene replacements were prepared. The quinoline 1c was an equipotent FXR agonist with improved drug developability...
10.
Brabec C, Gowrisanker S, Halls J, Laird D, Jia S, Williams S
Adv Mater
. 2010 Aug;
22(34):3839-56.
PMID: 20717982
Solution-processed bulk heterojunction organic photovoltaic (OPV) devices have gained serious attention during the last few years and are established as one of the leading next generation photovoltaic technologies for low...