Kevin P Madauss
Overview
Explore the profile of Kevin P Madauss including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
581
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0
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Recent Articles
1.
Martino J, Siri S, Calzetta N, Paviolo N, Garro C, Pansa M, et al.
Elife
. 2023 Nov;
12.
PMID: 37962330
No abstract available.
2.
Martino J, Siri S, Calzetta N, Paviolo N, Garro C, Pansa M, et al.
Elife
. 2023 Apr;
12.
PMID: 37073955
The trapping of Poly-ADP-ribose polymerase (PARP) on DNA caused by PARP inhibitors (PARPi) triggers acute DNA replication stress and synthetic lethality (SL) in BRCA2-deficient cells. Hence, DNA damage is accepted...
3.
Valenzuela-Vazquez L, Nunez-Enriquez J, Sanchez-Herrera J, Medina-Sanson A, Perez-Saldivar M, Jimenez-Hernandez E, et al.
Front Oncol
. 2022 Nov;
12:1023510.
PMID: 36419901
NK cells have unique attributes to react towards cells undergoing malignant transformation or viral infection. This reactivity is regulated by activating or inhibitory germline encoded receptors. An impaired NK cell...
4.
Gloger I, Felice R, Madauss K
Nat Rev Drug Discov
. 2021 Apr;
20(8):571-572.
PMID: 33846598
No abstract available.
5.
Carbajosa S, Pansa M, Paviolo N, Castellaro A, Andino D, Nigra A, et al.
Clin Cancer Res
. 2019 Mar;
25(13):4049-4062.
PMID: 30890549
Purpose: BRCA1 and BRCA2 deficiencies are widespread drivers of human cancers that await the development of targeted therapies. We aimed to identify novel synthetic lethal relationships with therapeutic potential using...
6.
Villafanez F, Garcia I, Carbajosa S, Pansa M, Mansilla S, Llorens M, et al.
Oncogene
. 2019 Feb;
38(22):4310-4324.
PMID: 30705406
Translesion DNA synthesis (TLS) and homologous recombination (HR) cooperate during S-phase to safeguard replication forks integrity. Thus, the inhibition of TLS becomes a promising point of therapeutic intervention in HR-deficient...
7.
Salas-Sarduy E, Uran Landaburu L, Karpiak J, Madauss K, Cazzulo J, Aguero F, et al.
Sci Rep
. 2018 Jun;
8(1):8743.
PMID: 29867193
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
8.
Salas-Sarduy E, Uran Landaburu L, Karpiak J, Madauss K, Cazzulo J, Aguero F, et al.
Sci Rep
. 2017 Sep;
7(1):12073.
PMID: 28935948
American Trypanosomiasis or Chagas disease is a prevalent, neglected and serious debilitating illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi. The current chemotherapy is limited only to nifurtimox and...
9.
Lobera M, Madauss K, Pohlhaus D, Wright Q, Trocha M, Schmidt D, et al.
Nat Chem Biol
. 2013 Mar;
9(5):319-25.
PMID: 23524983
In contrast to studies on class I histone deacetylase (HDAC) inhibitors, the elucidation of the molecular mechanisms and therapeutic potential of class IIa HDACs (HDAC4, HDAC5, HDAC7 and HDAC9) is...
10.
Akwabi-Ameyaw A, Caravella J, Chen L, Creech K, Deaton D, Madauss K, et al.
Bioorg Med Chem Lett
. 2011 Sep;
21(20):6154-60.
PMID: 21890356
To further explore the optimum placement of the acid moiety in conformationally constrained analogs of GW 4064 1a, a series of stilbene replacements were prepared. The benzothiophene 1f and the...