Sharon La Fontaine
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Explore the profile of Sharon La Fontaine including associated specialties, affiliations and a list of published articles.
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37
Citations
1281
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Recent Articles
1.
Blades B, Hung Y, Belaidi A, Volitakis I, Schultz A, Cater M, et al.
J Neurochem
. 2024 Aug;
168(9):3284-3307.
PMID: 39135362
The strongest genetic risk factor for late-onset Alzheimer's disease (AD) is allelic variation of the APOE gene, with the following risk structure: ε4 > ε3 > ε2. The biochemical basis...
2.
Blades B, Ayton S, Hung Y, Bush A, La Fontaine S
Biochim Biophys Acta Gen Subj
. 2021 Aug;
1865(11):129979.
PMID: 34364973
Background: Copper and lipid metabolism are intimately linked, sharing a complex, inverse relationship in the periphery (outside of the central nervous system), which remains to be fully elucidated. Scope: Copper...
3.
Maghool S, La Fontaine S, Roberts B, Kwan A, Maher M
Sci Rep
. 2020 Mar;
10(1):4157.
PMID: 32139726
Intracellular copper (Cu) in eukaryotic organisms is regulated by homeostatic systems, which rely on the activities of soluble metallochaperones that participate in Cu exchange through highly tuned protein-protein interactions. Recently,...
4.
Perez-Siles G, Cutrupi A, Ellis M, Kuriakose J, La Fontaine S, Mao D, et al.
Dis Model Mech
. 2020 Jan;
13(2).
PMID: 31969342
encodes a copper-transporting P-type ATPase and is one of 23 genes in which mutations produce distal hereditary motor neuropathy (dHMN), a group of diseases characterized by length-dependent axonal degeneration of...
5.
Maghool S, La Fontaine S, Maher M
Acta Crystallogr F Struct Biol Commun
. 2019 May;
75(Pt 5):392-396.
PMID: 31045569
Grx1, a cytosolic thiol-disulfide oxidoreductase, actively maintains cellular redox homeostasis using glutathione substrates (reduced, GSH, and oxidized, GSSG). Here, the crystallization of reduced Grx1 from the yeast Saccharomyces cerevisiae (yGrx1)...
6.
Xiao Z, La Fontaine S, Bush A, Wedd A
J Mol Biol
. 2018 Dec;
431(2):158-177.
PMID: 30552876
The tripeptide glutathione (GSH) and its oxidized form glutathione disulfide (GSSG) constitute a key redox couple in cells. In particular, they partner protein thiols in reversible thiol-disulfide exchange reactions that...
7.
Copper accumulation in senescent cells: Interplay between copper transporters and impaired autophagy
Masaldan S, Clatworthy S, Gamell C, Smith Z, Francis P, Denoyer D, et al.
Redox Biol
. 2018 Mar;
16:322-331.
PMID: 29579719
Cellular senescence is characterized by irreversible growth arrest incurred through either replicative exhaustion or by pro-oncogenic cellular stressors (radioactivity, oxidative stress, oncogenic activation). The enrichment of senescent cells in tissues...
8.
La Fontaine S, Burke R, Giedroc D
Metallomics
. 2016 Oct;
8(9):810-812.
PMID: 27714084
No abstract available.
9.
Perez-Siles G, Grant A, Ellis M, Ly C, Kidambi A, Khalil M, et al.
Metallomics
. 2016 Jun;
8(9):981-92.
PMID: 27293072
ATP7A is a P-type ATPase essential for cellular copper (Cu) transport and homeostasis. Loss-of-function ATP7A mutations causing systemic Cu deficiency are associated with severe Menkes disease or its milder allelic...
10.
Mercer S, La Fontaine S, Warr C, Burke R
J Neurochem
. 2016 Feb;
137(3):360-70.
PMID: 26851457
Glutathione (GSH) is a tripeptide often considered to be the master antioxidant in cells. GSH plays an integral role in cellular redox regulation and is also known to have a...