Michael A Cater
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Explore the profile of Michael A Cater including associated specialties, affiliations and a list of published articles.
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25
Citations
1309
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Recent Articles
1.
Blades B, Hung Y, Belaidi A, Volitakis I, Schultz A, Cater M, et al.
J Neurochem
. 2024 Aug;
168(9):3284-3307.
PMID: 39135362
The strongest genetic risk factor for late-onset Alzheimer's disease (AD) is allelic variation of the APOE gene, with the following risk structure: ε4 > ε3 > ε2. The biochemical basis...
2.
Meggyesy P, Masaldan S, Clatworthy S, Volitakis I, Eyckens D, Aston-Mourney K, et al.
Molecules
. 2020 Oct;
25(21).
PMID: 33120881
The therapeutic utility of the copper ionophore disulfiram was investigated in a diet-induced obesity mouse model (C57BL/6J background), both through administration in feed (0.05 to 1% ()) and via oral...
3.
Copper accumulation in senescent cells: Interplay between copper transporters and impaired autophagy
Masaldan S, Clatworthy S, Gamell C, Smith Z, Francis P, Denoyer D, et al.
Redox Biol
. 2018 Mar;
16:322-331.
PMID: 29579719
Cellular senescence is characterized by irreversible growth arrest incurred through either replicative exhaustion or by pro-oncogenic cellular stressors (radioactivity, oxidative stress, oncogenic activation). The enrichment of senescent cells in tissues...
4.
Denoyer D, Clatworthy S, Cater M
Met Ions Life Sci
. 2018 Feb;
18.
PMID: 29394035
Copper homeostasis is tightly regulated in both prokaryotic and eukaryotic cells to ensure sufficient amounts for cuproprotein biosynthesis, while limiting oxidative stress production and toxicity. Over the last century, copper...
5.
Masaldan S, Clatworthy S, Gamell C, Meggyesy P, Rigopoulos A, Haupt S, et al.
Redox Biol
. 2017 Sep;
14:100-115.
PMID: 28888202
Cellular senescence is characterised by the irreversible arrest of proliferation, a pro-inflammatory secretory phenotype and evasion of programmed cell death mechanisms. We report that senescence alters cellular iron acquisition and...
6.
Freestone D, Denoyer D, Jakab M, Ackland M, Cater M, Michalczyk A
Metallomics
. 2016 Jul;
8(9):941-50.
PMID: 27426449
Ceruloplasmin (Cp) is a multicopper ferroxidase that is considered to be an important source of copper in milk for normal neonatal development. We investigated the expression, subcellular localization and secretion...
7.
Denoyer D, Pearson H, Clatworthy S, Smith Z, Francis P, Llanos R, et al.
Oncotarget
. 2016 May;
7(24):37064-37080.
PMID: 27175597
Copper-ionophores that elevate intracellular bioavailable copper display significant therapeutic utility against prostate cancer cells in vitro and in TRAMP (Transgenic Adenocarcinoma of Mouse Prostate) mice. However, the pharmacological basis for...
8.
Yap Y, Llanos R, La Fontaine S, Cater M, Beart P, Cheung N
Neurochem Res
. 2015 Aug;
41(3):554-67.
PMID: 26318862
Mitochondrial dysfunction, ubiquitin-proteasomal system impairment and excitotoxicity occur during the injury and death of neurons in neurodegenerative conditions. The aim of this work was to elucidate the cellular mechanisms that...
9.
Denoyer D, Masaldan S, La Fontaine S, Cater M
Metallomics
. 2015 Aug;
7(11):1459-76.
PMID: 26313539
Copper is an essential micronutrient involved in fundamental life processes that are conserved throughout all forms of life. The ability of copper to catalyze oxidation-reduction (redox) reactions, which can inadvertently...
10.
Denoyer D, Clatworthy S, Masaldan S, Meggyesy P, Cater M
Prostate
. 2015 May;
75(14):1510-7.
PMID: 26012532
Background: Therapeutics that target copper for the treatment of prostate cancer are being evaluated in human clinical trials. Elevated intracellular copper is considered to sensitize prostate cancer cells to certain...