Sharon Heath
Overview
Explore the profile of Sharon Heath including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
5489
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0
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Recent Articles
1.
Wang T, Jacoby M, Duncavage E, Miller C, Heath S, Rahme R, et al.
Br J Haematol
. 2018 Nov;
185(5):984-987.
PMID: 30467844
No abstract available.
2.
Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia
Churpek J, Pyrtel K, Kanchi K, Shao J, Koboldt D, Miller C, et al.
Blood
. 2015 Oct;
126(22):2484-90.
PMID: 26492932
Familial clustering of myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML) can be caused by inherited factors. We screened 59 individuals from 17 families with 2 or more biological relatives...
3.
Wong T, Ramsingh G, Young A, Miller C, Touma W, Welch J, et al.
Nature
. 2014 Dec;
518(7540):552-555.
PMID: 25487151
Therapy-related acute myeloid leukaemia (t-AML) and therapy-related myelodysplastic syndrome (t-MDS) are well-recognized complications of cytotoxic chemotherapy and/or radiotherapy. There are several features that distinguish t-AML from de novo AML, including...
4.
Hughes A, Magrini V, Demeter R, Miller C, Fulton R, Fulton L, et al.
PLoS Genet
. 2014 Jul;
10(7):e1004462.
PMID: 25010716
Next-generation sequencing has been used to infer the clonality of heterogeneous tumor samples. These analyses yield specific predictions-the population frequency of individual clones, their genetic composition, and their evolutionary relationships-which...
5.
Walter M, Shen D, Ding L, Shao J, Koboldt D, Chen K, et al.
N Engl J Med
. 2012 Mar;
366(12):1090-8.
PMID: 22417201
Background: The myelodysplastic syndromes are a group of hematologic disorders that often evolve into secondary acute myeloid leukemia (AML). The genetic changes that underlie progression from the myelodysplastic syndromes to...
6.
Ding L, Ley T, Larson D, Miller C, Koboldt D, Welch J, et al.
Nature
. 2012 Jan;
481(7382):506-10.
PMID: 22237025
Most patients with acute myeloid leukaemia (AML) die from progressive disease after relapse, which is associated with clonal evolution at the cytogenetic level. To determine the mutational spectrum associated with...
7.
Graubert T, Shen D, Ding L, Okeyo-Owuor T, Lunn C, Shao J, et al.
Nat Genet
. 2011 Dec;
44(1):53-7.
PMID: 22158538
Myelodysplastic syndromes (MDS) are hematopoietic stem cell disorders that often progress to chemotherapy-resistant secondary acute myeloid leukemia (sAML). We used whole-genome sequencing to perform an unbiased comprehensive screen to discover...
8.
Welch J, Westervelt P, Ding L, Larson D, Klco J, Kulkarni S, et al.
JAMA
. 2011 Apr;
305(15):1577-84.
PMID: 21505136
Context: Whole-genome sequencing is becoming increasingly available for research purposes, but it has not yet been routinely used for clinical diagnosis. Objective: To determine whether whole-genome sequencing can identify cryptic,...
9.
Link D, Schuettpelz L, Shen D, Wang J, Walter M, Kulkarni S, et al.
JAMA
. 2011 Apr;
305(15):1568-76.
PMID: 21505135
Context: The identification of patients with inherited cancer susceptibility syndromes facilitates early diagnosis, prevention, and treatment. However, in many cases of suspected cancer susceptibility, the family history is unclear and...
10.
Ley T, Ding L, Walter M, McLellan M, Lamprecht T, Larson D, et al.
N Engl J Med
. 2010 Nov;
363(25):2424-33.
PMID: 21067377
Background: The genetic alterations responsible for an adverse outcome in most patients with acute myeloid leukemia (AML) are unknown. Methods: Using massively parallel DNA sequencing, we identified a somatic mutation...