Sharon Heath
Overview
Explore the profile of Sharon Heath including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
5489
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0
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Recent Articles
11.
Mardis E, Ding L, Dooling D, Larson D, McLellan M, Chen K, et al.
N Engl J Med
. 2009 Aug;
361(11):1058-66.
PMID: 19657110
Background: The full complement of DNA mutations that are responsible for the pathogenesis of acute myeloid leukemia (AML) is not yet known. Methods: We used massively parallel DNA sequencing to...
12.
Walter M, Payton J, Ries R, Shannon W, Deshmukh H, Zhao Y, et al.
Proc Natl Acad Sci U S A
. 2009 Aug;
106(31):12950-5.
PMID: 19651600
Cytogenetic analysis of acute myeloid leukemia (AML) cells has accelerated the identification of genes important for AML pathogenesis. To complement cytogenetic studies and to identify genes altered in AML genomes,...
13.
Ley T, Mardis E, Ding L, Fulton B, McLellan M, Chen K, et al.
Nature
. 2008 Nov;
456(7218):66-72.
PMID: 18987736
Acute myeloid leukaemia is a highly malignant haematopoietic tumour that affects about 13,000 adults in the United States each year. The treatment of this disease has changed little in the...
14.
Tomasson M, Xiang Z, Walgren R, Zhao Y, Kasai Y, Miner T, et al.
Blood
. 2008 Feb;
111(9):4797-808.
PMID: 18270328
Activating mutations in tyrosine kinase (TK) genes (eg, FLT3 and KIT) are found in more than 30% of patients with de novo acute myeloid leukemia (AML); many groups have speculated...
15.
Ley T, Minx P, Walter M, Ries R, Sun H, McLellan M, et al.
Proc Natl Acad Sci U S A
. 2003 Nov;
100(24):14275-80.
PMID: 14614138
In this pilot study, we used primary human acute myeloid leukemia (AML) cell genomes as templates for exonic PCR amplification, followed by high-throughput resequencing, analyzing approximately 7 million base pairs...