Sharon Gerecht
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Explore the profile of Sharon Gerecht including associated specialties, affiliations and a list of published articles.
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148
Citations
4117
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Recent Articles
1.
Guan Y, Zhang M, Song J, Negrete M, Adcock T, Kandel R, et al.
Adv Sci (Weinh)
. 2025 Mar;
:e2417778.
PMID: 40036145
Macrophages are essential for immune responses and maintaining tissue homeostasis, exhibiting a wide range of phenotypes depending on their microenvironment. The extracellular matrix (ECM) is a vital component that provides...
2.
Yang B, Rutkowski N, Ruta A, Gray-Gaillard E, Maestas D, Kelly S, et al.
bioRxiv
. 2025 Jan;
PMID: 39868312
Significance Statement: The foreign body response to implants leads to chronic inflammation and fibrosis that can be highly variable in the general patient population. Here, we demonstrate that gut dysbiosis...
3.
Ntekoumes D, Song J, Liu H, Amelung C, Guan Y, Gerecht S
Adv Healthc Mater
. 2024 Dec;
14(2):e2403860.
PMID: 39623803
Hypoxia elicits a multitude of tissue responses depending on the severity and duration of the exposure. While chronic hypoxia is shown to impact development, regeneration, and cancer, the understanding of...
4.
Wang D, Brady T, Santhanam L, Gerecht S
Nat Cardiovasc Res
. 2024 Aug;
2(8):718-732.
PMID: 39195965
Mechanical stimuli from the extracellular matrix (ECM) modulate vascular differentiation, morphogenesis and dysfunction of the vasculature. With innovation in measurements, we can better characterize vascular microenvironment mechanics in health and...
5.
Villares E, Gerecht S
ACS Biomater Sci Eng
. 2024 Aug;
10(9):5550-5561.
PMID: 39190867
The transcriptional coactivators yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are master regulators involved in a multitude of cancer types and a wide range of tumorigenic events,...
6.
Hall 3rd F, Miller C, Gerecht S, Boheler K
Stem Cell Res
. 2024 Jun;
79:103475.
PMID: 38941881
Marfan Syndrome, a connective tissue disorder caused by Fibrillin-1 (FBN1) gene mutations, induces disease in the ocular, musculoskeletal, and cardiovascular systems and increases aortic vulnerability to rupture associated with high...
7.
Fuller A, Pruitt H, Liu Y, Irizarry-Negron V, Pan H, Song H, et al.
J Clin Invest
. 2024 Apr;
134(11).
PMID: 38652549
CD8+ T cell dysfunction impedes antitumor immunity in solid cancers, but the underlying mechanisms are diverse and poorly understood. Extracellular matrix (ECM) composition has been linked to impaired T cell...
8.
Wei Z, Lei M, Wang Y, Xie Y, Xie X, Lan D, et al.
Nat Commun
. 2024 Apr;
15(1):3274.
PMID: 38627461
No abstract available.
9.
Marino-Bravante G, Carey A, Huser L, Dixit A, Wang V, Kaur A, et al.
Nat Aging
. 2024 Mar;
4(3):350-363.
PMID: 38472454
Melanoma, the most lethal form of skin cancer, often has worse outcomes in older patients. We previously demonstrated that an age-related decrease in the secreted extracellular matrix (ECM) protein HAPLN1...
10.
Tran A, Wisniewski E, Mistriotis P, Stoletov K, Parlani M, Amitrano A, et al.
Res Sq
. 2024 Jan;
PMID: 38260442
Cells migrating in confinement experience mechanical challenges whose consequences on cell migration machinery remain only partially understood. Here, we demonstrate that a pool of the cytokinesis regulatory protein anillin is...