Shantha K Mahadevaiah
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Explore the profile of Shantha K Mahadevaiah including associated specialties, affiliations and a list of published articles.
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Recent Articles
21.
Royo H, Prosser H, Ruzankina Y, Mahadevaiah S, Cloutier J, Baumann M, et al.
Genes Dev
. 2013 Jul;
27(13):1484-94.
PMID: 23824539
In mammals, homologs that fail to synapse during meiosis are transcriptionally inactivated. This process, meiotic silencing, drives inactivation of the heterologous XY bivalent in male germ cells (meiotic sex chromosome...
22.
Cocquet J, Ellis P, Mahadevaiah S, Affara N, Vaiman D, Burgoyne P
PLoS Genet
. 2012 Oct;
8(9):e1002900.
PMID: 23028340
Intragenomic conflicts arise when a genetic element favours its own transmission to the detriment of others. Conflicts over sex chromosome transmission are expected to have influenced genome structure, gene regulation,...
23.
Vernet N, Mahadevaiah S, Ellis P, de Rooij D, Burgoyne P
Reproduction
. 2012 Aug;
144(4):433-45.
PMID: 22869781
We recently used three XO male mouse models with varying Y short-arm (Yp) gene complements, analysed at 30 days post partum, to demonstrate a Yp gene requirement for the apoptotic...
24.
Grant J, Mahadevaiah S, Khil P, Sangrithi M, Royo H, Duckworth J, et al.
Nature
. 2012 Jun;
487(7406):254-8.
PMID: 22722828
In female (XX) mammals, one of the two X chromosomes is inactivated to ensure an equal dose of X-linked genes with males (XY). X-chromosome inactivation in eutherian mammals is mediated...
25.
Decarpentrie F, Vernet N, Mahadevaiah S, Longepied G, Streichemberger E, Aknin-Seifer I, et al.
Hum Mol Genet
. 2012 Mar;
21(12):2631-45.
PMID: 22407129
Mammalian ZFY genes are located on the Y chromosome, and code putative transcription factors with 12-13 zinc fingers preceded by a large acidic (activating) domain. In mice, there are two...
26.
Vernet N, Mahadevaiah S, Ojarikre O, Longepied G, Prosser H, Bradley A, et al.
Curr Biol
. 2011 May;
21(9):787-93.
PMID: 21530259
During male but not female mammalian meiosis, there is efficient apoptotic elimination of cells with unpaired (univalent) chromosomes at the first meiotic metaphase (MI) [1]. Apoptotic elimination of MI spermatocytes...
27.
Royo H, Polikiewicz G, Mahadevaiah S, Prosser H, Mitchell M, Bradley A, et al.
Curr Biol
. 2010 Nov;
20(23):2117-23.
PMID: 21093264
The mammalian X and Y chromosomes share little homology and are largely unsynapsed during normal meiosis. This asynapsis triggers inactivation of X- and Y-linked genes, or meiotic sex chromosome inactivation...
28.
Cocquet J, Ellis P, Yamauchi Y, Mahadevaiah S, Affara N, Ward M, et al.
PLoS Biol
. 2009 Nov;
7(11):e1000244.
PMID: 19918361
Studies of mice with Y chromosome long arm deficiencies suggest that the male-specific region (MSYq) encodes information required for sperm differentiation and postmeiotic sex chromatin repression (PSCR). Several genes have...
29.
Mahadevaiah S, Royo H, VandeBerg J, McCarrey J, Mackay S, Turner J
Curr Biol
. 2009 Sep;
19(17):1478-84.
PMID: 19716301
In female marsupials, X chromosome inactivation (XCI) is imprinted, affecting the paternal X chromosome. One model, supported by recent studies, proposes that XCI in marsupials is achieved through inheritance of...
30.
Mahadevaiah S, Costa Y, Turner J
Methods Mol Biol
. 2009 Aug;
558:433-44.
PMID: 19685339
During mouse meiosis, gene expression and homologous synapsis are intimately linked. Chromosomes that fail to synapse at the zygotene-pachytene transition become transcriptionally silenced by a process called Meiotic Silencing of...