Shantha K Mahadevaiah
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Explore the profile of Shantha K Mahadevaiah including associated specialties, affiliations and a list of published articles.
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44
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2518
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Recent Articles
11.
Cocquet J, Ellis P, Mahadevaiah S, Affara N, Vaiman D, Burgoyne P
PLoS Genet
. 2019 Jul;
15(7):e1008290.
PMID: 31329581
[This corrects the article DOI: 10.1371/journal.pgen.1002900.].
12.
Hirota T, Blakeley P, Sangrithi M, Mahadevaiah S, Encheva V, Snijders A, et al.
Dev Cell
. 2018 Nov;
47(5):645-659.e6.
PMID: 30393076
Meiotic synapsis and recombination ensure correct homologous segregation and genetic diversity. Asynapsed homologs are transcriptionally inactivated by meiotic silencing, which serves a surveillance function and in males drives meiotic sex...
13.
Widger A, Mahadevaiah S, Lange J, Elinati E, Zohren J, Hirota T, et al.
Nat Commun
. 2018 Jul;
9(1):2621.
PMID: 29976923
Meiotic cells undergo genetic exchange between homologs through programmed DNA double-strand break (DSB) formation, recombination and synapsis. In mice, the DNA damage-regulated phosphatidylinositol-3-kinase-like kinase (PIKK) ATM regulates all of these...
14.
Hirota T, Ohta H, Powell B, Mahadevaiah S, Ojarikre O, Saitou M, et al.
Science
. 2017 Aug;
357(6354):932-935.
PMID: 28818972
Having the correct number of chromosomes is vital for normal development and health. Sex chromosome trisomy affects 0.1% of the human population and is associated with infertility. We show that...
15.
Sangrithi M, Royo H, Mahadevaiah S, Ojarikre O, Bhaw L, Sesay A, et al.
Dev Cell
. 2017 Jan;
40(3):289-301.e3.
PMID: 28132849
Somatic X dosage compensation requires two mechanisms: X inactivation balances X gene output between males (XY) and females (XX), while X upregulation, hypothesized by Ohno and documented in vivo, balances...
16.
Vernet N, Mahadevaiah S, de Rooij D, Burgoyne P, Ellis P
Hum Mol Genet
. 2016 Oct;
25(24):5300-5310.
PMID: 27742779
During spermatogenesis, germ cells that fail to synapse their chromosomes or fail to undergo meiotic sex chromosome inactivation (MSCI) are eliminated via apoptosis during mid-pachytene. Previous work showed that Y-linked...
17.
Vernet N, Mahadevaiah S, Decarpentrie F, Longepied G, de Rooij D, Burgoyne P, et al.
PLoS One
. 2016 Jan;
11(1):e0145398.
PMID: 26765744
A previous study indicated that genetic information encoded on the mouse Y chromosome short arm (Yp) is required for efficient completion of the second meiotic division (that generates haploid round...
18.
Cloutier J, Mahadevaiah S, Elinati E, Nussenzweig A, Toth A, Turner J
PLoS Genet
. 2015 Oct;
11(10):e1005462.
PMID: 26509888
Chromosome abnormalities are common in the human population, causing germ cell loss at meiotic prophase I and infertility. The mechanisms driving this loss are unknown, but persistent meiotic DNA damage...
19.
Vernet N, Mahadevaiah S, Yamauchi Y, Decarpentrie F, Mitchell M, Ward M, et al.
PLoS Genet
. 2014 Jun;
10(6):e1004444.
PMID: 24967676
Mouse Zfy1 and Zfy2 encode zinc finger transcription factors that map to the short arm of the Y chromosome (Yp). They have previously been shown to promote meiotic quality control...
20.
Vernet N, Szot M, Mahadevaiah S, Ellis P, Decarpentrie F, Ojarikre O, et al.
Development
. 2014 Feb;
141(4):855-66.
PMID: 24496622
Outbred XY(Sry-) female mice that lack Sry due to the 11 kb deletion Sry(dl1Rlb) have very limited fertility. However, five lines of outbred XY(d) females with Y chromosome deletions Y(Del(Y)1Ct)-Y(Del(Y)5Ct)...