Shannon E Townsend
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Explore the profile of Shannon E Townsend including associated specialties, affiliations and a list of published articles.
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7
Citations
97
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Recent Articles
1.
Townsend S, Fuhr J, Gannon M
Am J Physiol Endocrinol Metab
. 2023 Aug;
325(3):E280-E290.
PMID: 37529833
Stimulation of functional β-cell mass expansion can be beneficial for the treatment of type 2 diabetes. Our group has previously demonstrated that the matricellular protein CCN2 can induce β-cell mass...
2.
Jouvet N, Bouyakdan K, Campbell S, Baldwin C, Townsend S, Gannon M, et al.
Diabetes
. 2021 Oct;
70(12):2850-2859.
PMID: 34610983
Controllable genetic manipulation is an indispensable tool in research, greatly advancing our understanding of cell biology and physiology. However in β-cells, transgene silencing, low inducibility, ectopic expression, and off-targets effects...
3.
Mosleh E, Ou K, Haemmerle M, Tembo T, Yuhas A, Carboneau B, et al.
Endocrinology
. 2020 Apr;
161(8).
PMID: 32267917
Targeted gene ablation studies of the endocrine pancreas have long suffered from suboptimal Cre deleter strains. In many cases, Cre lines purportedly specific for beta cells also displayed expression in...
4.
Townsend S, Gannon M
Endocrinology
. 2019 Jul;
160(8):1885-1894.
PMID: 31271410
This review describes formation of the islet basement membrane and the function of extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for islet transplantation are discussed. The insulin-producing...
5.
Seferovic M, Beamish C, Mosser R, Townsend S, Pappan K, Poitout V, et al.
Am J Physiol Endocrinol Metab
. 2018 Aug;
315(6):E1251-E1263.
PMID: 30106624
Pancreatic β-cell expansion is a highly regulated metabolic adaptation to increased somatic demands, including obesity and pregnancy; adult β cells otherwise rarely proliferate. We previously showed that high-fat diet (HFD)...
6.
Carboneau B, Allan J, Townsend S, Kimple M, Breyer R, Gannon M
Mol Metab
. 2017 Jun;
6(6):548-559.
PMID: 28580285
Objective: Hyperglycemia and systemic inflammation, hallmarks of Type 2 Diabetes (T2D), can induce the production of the inflammatory signaling molecule Prostaglandin E (PGE) in islets. The effects of PGE are...
7.
Turgeon S, Townsend S, Dixon R, Hickman E, Lee S
Pharmacol Biochem Behav
. 2016 Feb;
143:26-33.
PMID: 26850920
Caffeine consumption has been increasing rapidly in adolescents; however, most research on the behavioral effects of caffeine has been conducted in adults. Two experiments were conducted in which adolescent male...