Shankar Balasubramanian
Overview
Explore the profile of Shankar Balasubramanian including associated specialties, affiliations and a list of published articles.
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266
Citations
18541
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Recent Articles
1.
Awwad S, Doyle C, Coulthard J, Bader A, Gueorguieva N, Lam S, et al.
Nat Commun
. 2025 Jan;
16(1):480.
PMID: 39779698
ATR plays key roles in cellular responses to DNA damage and replication stress, a pervasive feature of cancer cells. ATR inhibitors (ATRi) are in clinical development for treating various cancers,...
2.
Balasubramanian S, McDowell E, Laryea E, Blankenstein G, Pamidi P, Winkler A, et al.
Clin Chem
. 2024 Sep;
70(12):1485-1493.
PMID: 39293997
Background: Preanalytical error due to hemolyzed blood samples is a common challenge in laboratory and point-of-care (POC) settings. Whole blood potassium (K+) measurements routinely measured on blood gas analyzers are...
3.
Yan T, Chen Y, Mortishire-Smith B, Simeone A, Hofer A, Balasubramanian S
Angew Chem Int Ed Engl
. 2024 Sep;
64(1):e202413593.
PMID: 39231378
Selective C-H activation on complex biological macromolecules is a key goal in the field of organic chemistry. It requires thermodynamically challenging chemical transformations to be delivered under mild, aqueous conditions....
4.
Flynn S, Dhir S, Herka K, Doyle C, Melidis L, Simeone A, et al.
Genome Biol
. 2024 Sep;
25(1):237.
PMID: 39227991
Methods to measure chromatin contacts at genomic regions bound by histone modifications or proteins are important tools to investigate chromatin organization. However, such methods do not capture the possible involvement...
5.
Carnie C, Acampora A, Bader A, Erdenebat C, Zhao S, Bitensky E, et al.
Nat Cell Biol
. 2024 Apr;
26(5):797-810.
PMID: 38600235
Covalent DNA-protein cross-links (DPCs) are toxic DNA lesions that block replication and require repair by multiple pathways. Whether transcription blockage contributes to the toxicity of DPCs and how cells respond...
6.
Simpson M, Lam C, Goodman J, Balasubramanian S
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
135(26):e202304756.
PMID: 38516645
The epigenetic modification 5-methylcytosine plays a vital role in development, cell specific gene expression and disease states. The selective chemical modification of the 5-methylcytosine methyl group is challenging. Currently, no...
7.
Chen Y, Simeone A, Melidis L, Martinez Cuesta S, Tannahill D, Balasubramanian S
ACS Chem Biol
. 2024 Feb;
19(3):736-742.
PMID: 38417105
Four-stranded G-quadruplexes (G4s) are DNA secondary structures that can form in the human genome. G4 structures have been detected in gene promoters and are associated with transcriptionally active chromatin and...
8.
Esain-Garcia I, Kirchner A, Melidis L, Araujo Tavares R, Dhir S, Simeone A, et al.
Proc Natl Acad Sci U S A
. 2024 Feb;
121(7):e2320240121.
PMID: 38315865
DNA structure can regulate genome function. Four-stranded DNA G-quadruplex (G4) structures have been implicated in transcriptional regulation; however, previous studies have not directly addressed the role of an individual G4...
9.
Qu X, Lin Z, Jayawickramarajah J, Alsager J, Schmidt E, Nephew K, et al.
iScience
. 2023 Dec;
26(12):108559.
PMID: 38144452
The cancer-promoting lncRNA HOTAIR has multiple isoforms. Which isoform of HOTAIR accounts for its expression and functions in cancer is unknown. Unlike HOTAIR's canonical intergenic isoform NR_003716 (HOTAIR-C), the novel...
10.
Serrano-Benitez A, Wells S, Drummond-Clarke L, Russo L, Thomas J, Leal G, et al.
EMBO J
. 2023 Jul;
42(18):e113190.
PMID: 37492888
DNA single-strand breaks (SSBs) disrupt DNA replication and induce chromosome breakage. However, whether SSBs induce chromosome breakage when present behind replication forks or ahead of replication forks is unclear. To...