Sham S Kakar
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Explore the profile of Sham S Kakar including associated specialties, affiliations and a list of published articles.
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67
Citations
1293
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Recent Articles
1.
Kakar S, Vemuri V, Ratajczak M
Cells
. 2025 Feb;
14(4).
PMID: 39996717
Cachexia is a multifactorial syndrome characterized by severe muscle wasting and is a debilitating condition frequently associated with cancer. Previous studies from our group revealed that withaferin A (WFA), a...
2.
PAF1-mediated transcriptional reprogramming confers docetaxel resistance in advanced prostate cancer
Muniyan S, Vengoji R, Nimmakayala R, Seshacharyulu P, Perumalsamy B, Alsafwani Z, et al.
Cancer Lett
. 2024 Nov;
609():217355.
PMID: 39603380
Advanced prostate cancer (PCa) remains a significant clinical challenge, and docetaxel plays a significant role in disease management. Despite the efficacy of docetaxel as a first-line chemotherapy, resistance often develops....
3.
Kumar K, Bosch K, Vemuri V, Kratholm N, Rane M, Kakar S
J Ovarian Res
. 2024 Oct;
17(1):199.
PMID: 39394174
Background: Cachexia a multifactorial syndrome is a common sequala in patients with cancer. It varies from 42 to 80% depending upon the oncological stage and is directly responsible for 30%...
4.
Vemuri V, Kratholm N, Nagarajan D, Cathey D, Abdelbaset-Ismail A, Tan Y, et al.
Cells
. 2024 May;
13(9.
PMID: 38727319
In our previous studies, we showed that the generation of ovarian tumors in NSG mice (immune-compromised) resulted in the induction of muscle and cardiac cachexia, and treatment with withaferin A...
5.
Saha S, Singh P, Roy P, Kakar S
Cells
. 2022 Mar;
11(6).
PMID: 35326441
Tumor-derived cachectic factors such as proinflammatory cytokines and neuromodulators not only affect skeletal muscle but also affect other organs, including the heart, in the form of cardiac muscle atrophy, fibrosis,...
6.
Haldar S, Agrawal H, Saha S, Straughn A, Roy P, Kakar S
Int J Biol Sci
. 2022 Jan;
18(2):675-692.
PMID: 35002517
Follicle stimulating hormone (FSH) and its receptor (FSHR) have been reported to be responsible for several physiological functions and cancers. The responsiveness of stem cells and cancer stem cells towards...
7.
8.
Kakar S, Ratajczak M
Stem Cell Rev Rep
. 2021 Aug;
17(5):1519-1520.
PMID: 34448117
No abstract available.
9.
Saha S, Parte S, Roy P, Kakar S
Adv Exp Med Biol
. 2021 Aug;
1330:151-169.
PMID: 34339036
Ovarian cancer is a heterogenous disease with variable clinicopathological and molecular mechanisms being responsible for tumorigenesis. Despite substantial technological improvement, lack of early diagnosis contributes to its highest mortality. Ovarian...
10.
Saha S, Roy P, Corbitt C, Kakar S
Cells
. 2021 Jul;
10(7).
PMID: 34203240
Infertility creates an immense impact on the psychosocial wellbeing of affected couples, leading to poor quality of life. Infertility is now considered to be a global health issue affecting approximately...