Shalini Jha
Overview
Explore the profile of Shalini Jha including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
228
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Recent Articles
1.
Nohara J, Evangelous T, Berry M, Beck W, Mudrak S, Jha S, et al.
Pathog Immun
. 2025 Feb;
10(1):49-79.
PMID: 39911143
Background: Antibody-dependent cell-mediated cytotoxic (ADCC) response mediated by natural killer (NK) cells correlates with decreased infection risk in studies involving simian immunodeficiency virus (SIV)/simian-human immunodeficiency virus (SHIV), and human immunodeficiency...
2.
DeLuca J, Blasi M, Jha S, Shen X, Pollara J, Kerkau M, et al.
Res Sq
. 2024 Apr;
PMID: 38659814
Diverse and rapidly mutating viruses pose challenges to immunogen and vaccine design. In this study, we evaluated the ability of memory B-cells obtained from two independent NHP trials to cross-react...
3.
Tuyishime M, Spreng R, Hueber B, Nohara J, Goodman D, Chan C, et al.
Front Immunol
. 2023 Dec;
14:1260377.
PMID: 38124734
Rhesus macaques (RMs) are a common pre-clinical model used to test HIV vaccine efficacy and passive immunization strategies. Yet, it remains unclear to what extent the Fc-Fc receptor (FcR) interactions...
4.
Xu S, Carpenter M, Spreng R, Neidich S, Sarkar S, Tenney D, et al.
NPJ Vaccines
. 2022 Aug;
7(1):90.
PMID: 35927399
Adjuvants can alter the magnitude, characteristics, and persistence of the humoral response to protein vaccination. HIV vaccination might benefit from tailored adjuvant choice as raising a durable and protective response...
5.
Mielke D, Stanfield-Oakley S, Jha S, Keyes T, Zalaquett A, Dunn B, et al.
Cytometry A
. 2022 Mar;
101(6):483-496.
PMID: 35301794
Since the beginning of the SARS-CoV-2 pandemic, antibody responses and antibody effector functions targeting SARS-CoV-2-infected cells have been understudied. Consequently, the role of these types of antibodies in SARS-CoV-2 disease...
6.
Tolbert W, Nguyen D, Tuyishime M, Crowley A, Chen Y, Jha S, et al.
Front Immunol
. 2022 Jan;
12:787603.
PMID: 35069563
Passive transfer of monoclonal antibodies (mAbs) of human origin into Non-Human Primates (NHPs), especially those which function predominantly by a Fc-effector mechanism, requires an preparation step, in which the human...
7.
Mitchell J, Pollara J, Dietze K, Edwards R, Nohara J, Nguessan K, et al.
J Clin Invest
. 2021 Nov;
132(1).
PMID: 34762600
Early initiation of antiretroviral therapy (ART) in acute HIV infection (AHI) is effective at limiting seeding of the HIV viral reservoir, but little is known about how the resultant decreased...
8.
Tuyishime M, Dashti A, Faircloth K, Jha S, Nordstrom J, Haynes B, et al.
Front Immunol
. 2021 Sep;
12:710273.
PMID: 34484212
Bispecific HIVxCD3 DART molecules that co-engage the viral envelope glycoprotein (Env) on HIV-1-infected cells and the CD3 receptor on CD3+ T cells are designed to mediate the cytolysis of HIV-1-infected,...
9.
Pollara J, Tay M, Edwards R, Goodman D, Crowley A, Edwards R, et al.
Front Immunol
. 2021 Jun;
12:678511.
PMID: 34093580
Analyses of human clinical HIV-1 vaccine trials and preclinical vaccine studies performed in rhesus macaque (RM) models have identified associations between non-neutralizing Fc Receptor (FcR)-dependent antibody effector functions and reduced...
10.
Tuyishime M, Garrido C, Jha S, Moeser M, Mielke D, LaBranche C, et al.
J Clin Invest
. 2020 Jun;
130(10):5157-5170.
PMID: 32584790
The correlation of HIV-specific antibody-dependent cellular cytotoxicity (ADCC) responses with protection from and delayed progression of HIV-1 infection provides a rationale to leverage ADCC-mediating antibodies for treatment purposes. We evaluated...