R Whitney Edwards
Overview
Explore the profile of R Whitney Edwards including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
248
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Recent Articles
1.
Pollara J, Khanal S, Edwards R, Hora B, Ferrari G, Haynes B, et al.
BMC Immunol
. 2022 Sep;
23(1):48.
PMID: 36175869
Background: Cellular immune responses are phenotypically and functionally perturbed during HIV-1 infection, with the majority of function restored upon antiretroviral therapy (ART). Despite ART, residual inflammation remains that can lead...
2.
Mitchell J, Pollara J, Dietze K, Edwards R, Nohara J, Nguessan K, et al.
J Clin Invest
. 2021 Nov;
132(1).
PMID: 34762600
Early initiation of antiretroviral therapy (ART) in acute HIV infection (AHI) is effective at limiting seeding of the HIV viral reservoir, but little is known about how the resultant decreased...
3.
Pollara J, Tay M, Edwards R, Goodman D, Crowley A, Edwards R, et al.
Front Immunol
. 2021 Jun;
12:678511.
PMID: 34093580
Analyses of human clinical HIV-1 vaccine trials and preclinical vaccine studies performed in rhesus macaque (RM) models have identified associations between non-neutralizing Fc Receptor (FcR)-dependent antibody effector functions and reduced...
4.
Halpern S, Rush C, Edwards R, Brennan T, Barbas A, Pollara J
Exp Clin Transplant
. 2021 Apr;
19(7):635-644.
PMID: 33877036
Objectives: Complement activation in organs from deceased donors is associated with allograft injury and acute rejection. Because use of organs from donors after circulatory death is increasing, we characterized relative...
5.
Pollara J, Edwards R, Jha S, Lam C, Liu L, Diedrich G, et al.
Front Immunol
. 2020 May;
11:713.
PMID: 32373131
Mother-to-child transmission of HIV-1 remains a major global health challenge. Currently, HIV-1-infected infants require strict lifelong adherence to antiretroviral therapy to prevent replication of virus from reservoirs of infected cells,...
6.
Fisher L, Zinter M, Stanfield-Oakley S, Carpp L, Edwards R, Denny T, et al.
Front Immunol
. 2019 Dec;
10:2741.
PMID: 31827470
The secondary analyses for correlates of risk of infection in the RV144 HIV-1 vaccine trial implicated vaccine-induced antibody-dependent cellular cytotoxicity (ADCC) responses in the observed protection, highlighting the importance of...
7.
Pollara J, Jones D, Huffman T, Edwards R, Dennis M, Li S, et al.
J Virol
. 2019 Mar;
93(10).
PMID: 30842326
Studies in animal models are essential prerequisites for clinical trials of candidate HIV vaccines. Small animals, such as rabbits, are used to evaluate promising strategies prior to further immunogenicity and...
8.
Bradley T, Peppa D, Pedroza-Pacheco I, Li D, Cain D, Henao R, et al.
Cell
. 2018 Oct;
175(2):387-399.e17.
PMID: 30270043
HIV-1 broadly neutralizing antibodies (bnAbs) are difficult to induce with vaccines but are generated in ∼50% of HIV-1-infected individuals. Understanding the molecular mechanisms of host control of bnAb induction is...
9.
Pollara J, Edwards R, Lin L, Bendersky V, Brennan T
JCI Insight
. 2018 Aug;
3(15).
PMID: 30089724
Brain death that occurs in the setting of deceased organ donation for transplantation is associated with systemic inflammation of unknown origin. It has recently been recognized that mitochondria-derived damage-associated molecular...
10.
Nguyen Q, Martinez D, Himes J, Edwards R, Han Q, Kumar A, et al.
Retrovirology
. 2018 Mar;
15(1):24.
PMID: 29523166
Background: The initial envelope (Env)-specific antibody response in acutely HIV-1-infected individuals and simian immunodeficiency virus (SIV)-infected rhesus monkeys (RMs) is dominated by non-neutralizing antibodies targeting Env gp41. In contrast, natural...