Seth L Robia
Overview
Explore the profile of Seth L Robia including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
65
Citations
1148
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Cunningham J, Phillips T, Seflova J, Cho E, Robia S
Cell Calcium
. 2025 Feb;
126:103000.
PMID: 39921961
To determine how regulation of the sarco(endo)plasmic reticulum calcium ATPase (SERCA) affects the Ca content of the endoplasmic reticulum (ER), we developed a ratiometric ER-localized Ca indicator to rapidly quantify...
2.
Cleary S, Teng A, Kongmeneck A, Fang X, Phillips T, Cho E, et al.
J Biol Chem
. 2024 Dec;
301(2):108118.
PMID: 39710323
The sarco(endo)plasmic reticulum Ca ATPase (SERCA) is a membrane transporter that creates and maintains intracellular Ca stores. In the heart, SERCA is regulated by an inhibitory interaction with the monomeric...
3.
Hassel K, Gibson A, Seflova J, Cho E, Blair N, Van Raamsdonk C, et al.
J Mol Cell Cardiol
. 2024 Oct;
197:45-58.
PMID: 39437886
Calcium (Ca) dysregulation is a hallmark feature of cardiovascular disease. Intracellular Ca regulation is essential for proper heart function and is controlled by the sarco/endoplasmic reticulum Ca ATPase (SERCA2a). Another-regulin...
4.
Weber D, Reddy U, Robia S, Veglia G
Biochim Biophys Acta Biomembr
. 2024 Jul;
1866(7):184370.
PMID: 38986894
Phospholamban (PLN) is a 52 amino acid regulin that allosterically modulates the activity of the sarco(endo)plasmic reticulum Ca-ATPase (SERCA) in the heart muscle. In its unphosphorylated form, PLN binds SERCA...
5.
Bovo E, Jamrozik T, Kahn D, Karkut P, Robia S, Zima A
Cell Calcium
. 2024 Jun;
121:102910.
PMID: 38823350
In cardiac myocytes, the type 2a sarco/endoplasmic reticulum Ca-ATPase (SERCA2a) plays a key role in intracellular Ca regulation. Due to its critical role in heart function, SERCA2a activity is tightly...
6.
Bovo E, Seflova J, Robia S, Zima A
Pflugers Arch
. 2024 May;
476(7):1077-1086.
PMID: 38769127
Diabetes is commonly associated with an elevated level of reactive carbonyl species due to alteration of glucose and fatty acid metabolism. These metabolic changes cause an abnormality in cardiac Ca...
7.
Cleary S, Seflova J, Cho E, Bisht K, Khandelia H, Espinoza-Fonseca L, et al.
J Biol Chem
. 2024 Apr;
300(5):107267.
PMID: 38583863
Phospholamban (PLB) is a transmembrane micropeptide that regulates the sarcoplasmic reticulum Ca-ATPase (SERCA) in cardiac muscle, but the physical mechanism of this regulation remains poorly understood. PLB reduces the Ca...
8.
Bovo E, Seflova J, Robia S, Zima A
Res Sq
. 2024 Mar;
PMID: 38464201
Diabetes is commonly associated with an elevated level of reactive carbonyl species due to alteration of glucose and fatty acid metabolism. These metabolic changes cause an abnormality in cardiac Ca...
9.
Seflova J, Cruz-Cortes C, Guerrero-Serna G, Robia S, Espinoza-Fonseca L
PNAS Nexus
. 2024 Jan;
3(1):pgad453.
PMID: 38222469
The discovery of allosteric modulators is an emerging paradigm in drug discovery, and signal transduction is a subtle and dynamic process that is challenging to characterize. We developed a time-correlated...
10.
Seflova J, Schwarz J, Smith A, Svensson B, Blackwell D, Phillips T, et al.
ACS Chem Biol
. 2023 Sep;
18(10):2290-2299.
PMID: 37769131
Hyperactivity of cardiac sarcoplasmic reticulum (SR) ryanodine receptor (RyR2) Ca-release channels contributes to heart failure and arrhythmias. Reducing the RyR2 activity, particularly during cardiac relaxation (diastole), is a desirable therapeutic...