Sergi Regot
Overview
Explore the profile of Sergi Regot including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
1550
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0
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Recent Articles
1.
Hoffman T, Tian C, Nangia V, Yang C, Regot S, Gerosa L, et al.
Cell Syst
. 2025 Jan;
16(1):101162.
PMID: 39818199
The mitogen-activated protein kinase (MAPK) pathway integrates growth factor signaling through extracellular signal-regulated kinase (ERK) to control cell proliferation. To study ERK dynamics, many researchers use an ERK activity kinase...
2.
Sinha N, McKenney C, Yeow Z, Li J, Nam K, Yaron-Barir T, et al.
Cell
. 2024 Jun;
187(14):3652-3670.e40.
PMID: 38843833
While ultraviolet (UV) radiation damages DNA, eliciting the DNA damage response (DDR), it also damages RNA, triggering transcriptome-wide ribosomal collisions and eliciting a ribotoxic stress response (RSR). However, the relative...
3.
McKenney C, Lendner Y, Guerrero Zuniga A, Sinha N, Veresko B, Aikin T, et al.
Science
. 2024 May;
384(6695):eadi2421.
PMID: 38696576
Cell cycle events are coordinated by cyclin-dependent kinases (CDKs) to ensure robust cell division. CDK4/6 and CDK2 regulate the growth 1 (G) to synthesis (S) phase transition of the cell...
4.
Xin T, Gallini S, Wei H, Gonzalez D, Matte-Martone C, Machida H, et al.
Nat Cell Biol
. 2024 Apr;
26(6):859-867.
PMID: 38689013
Tissue regeneration and maintenance rely on coordinated stem cell behaviours. This orchestration can be impaired by oncogenic mutations leading to cancer. However, it is largely unclear how oncogenes perturb stem...
5.
Guerrero Zuniga A, Aikin T, McKenney C, Lendner Y, Phung A, Hook P, et al.
Dev Cell
. 2024 Apr;
59(13):1724-1736.e4.
PMID: 38640927
Whole-genome duplication (WGD) is a frequent event in cancer evolution that fuels chromosomal instability. WGD can result from mitotic errors or endoreduplication, yet the molecular mechanisms that drive WGD remain...
6.
Wei H, Du S, Parksong J, Pasolli H, Matte-Martone C, Regot S, et al.
Cell Stem Cell
. 2023 Jul;
30(7):962-972.e6.
PMID: 37419106
The ability of stem cells to build and replenish tissues depends on support from their niche. Although niche architecture varies across organs, its functional importance is unclear. During hair follicle...
7.
Peterson A, Ingram K, Huang E, Parksong J, McKenney C, Bever G, et al.
Cell Syst
. 2022 Nov;
13(11):885-894.e4.
PMID: 36356576
The classic network of mitogen-activated protein kinases (MAPKs) is highly interconnected and controls a diverse array of biological processes. In multicellular eukaryotes, the MAPKs ERK, JNK, and p38 control opposing...
8.
Wang Q, Hernandez-Ochoa E, Viswanathan M, Blum I, Do D, Granger J, et al.
Nat Commun
. 2021 May;
12(1):3175.
PMID: 34039988
Antagonistic pleiotropy is a foundational theory that predicts aging-related diseases are the result of evolved genetic traits conferring advantages early in life. Here we examine CaMKII, a pluripotent signaling molecule...
9.
Pokrass M, Regot S
STAR Protoc
. 2021 Apr;
2(2):100446.
PMID: 33899025
Determining how signaling dynamics relate to gene expression and cell fate is essential to understanding multicellular development. We present a unified live imaging and lineage analysis method that allows integrated...
10.
Clark H, McKenney C, Livingston N, Gershman A, Sajjan S, Chan I, et al.
Nat Commun
. 2021 Mar;
12(1):1836.
PMID: 33758175
To prevent damage to the host or its commensal microbiota, epithelial tissues must match the intensity of the immune response to the severity of a biological threat. Toll-like receptors allow...