Seiichi Ishizuka
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Explore the profile of Seiichi Ishizuka including associated specialties, affiliations and a list of published articles.
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26
Citations
162
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Recent Articles
1.
Teramachi J, Hiruma Y, Ishizuka S, Ishizuka H, Brown J, Michou L, et al.
J Bone Miner Res
. 2013 Feb;
28(6):1489-500.
PMID: 23426901
Osteoclast (OCL) precursors from many Paget's disease (PD) patients express measles virus nucleocapsid protein (MVNP) and are hypersensitive to 1,25-dihydroxyvitamin D₂ (1,25-(OH)₂D₃; also know as calcitriol). The increased 1,25-(OH)₂D₃ sensitivity...
2.
Takano Y, Mitsuhashi H, Ishizuka S, Takahashi K, Chokki M, Takenouchi K, et al.
Steroids
. 2012 Oct;
77(14):1535-42.
PMID: 23046766
While searching for vitamin D(3) analogues which inhibit neutrophil recruitment in the lung without elevating plasma calcium level, we found that (5Z,7E)-(1S,3R)-20(R)-[(5E)-(2S)-2-hydroxy-2-methyl-cyclopentanone-5-ylidene]methyl-9,10-secopregna-5,7,10(19)-triene-1,3-diol (TEI-A00114) had the best efficacy and calcemic action....
3.
Shindo K, Kumagai G, Takano M, Sawada D, Saito N, Saito H, et al.
Org Lett
. 2011 May;
13(11):2852-5.
PMID: 21539305
C15-Substituted 1α,25-dihydroxyvitamin D(3) analogs were synthesized for the first time to investigate the effects of the modified CD-ring on biological activity concerning the agonistic positioning of helix-3 and helix-12 of...
4.
Kakuda S, Ishizuka S, Eguchi H, Mizwicki M, Norman A, Takimoto-Kamimura M
Acta Crystallogr D Biol Crystallogr
. 2010 Aug;
66(Pt 8):918-26.
PMID: 20693691
TEI-9647 antagonizes vitamin D receptor (VDR) mediated genomic actions of 1alpha,25(OH)2D3 in human cells but is agonistic in rodent cells. The presence of Cys403, Cys410 or of both residues in...
5.
Sawada D, Tsukuda Y, Saito H, Takagi K, Ochiai E, Ishizuka S, et al.
J Steroid Biochem Mol Biol
. 2010 Mar;
121(1-2):20-4.
PMID: 20214990
2beta-substituted analogs of 14-epi-previtamin D(3) were synthesized for the first time by the thermal isomerization of the corresponding 14-epi-vitamin D3 that were available using coupling reaction between the A-ring phosphine...
6.
Mizwicki M, Bula C, Mahinthichaichan P, Henry H, Ishizuka S, Norman A
J Biol Chem
. 2009 Oct;
284(52):36292-36301.
PMID: 19801650
(23S)-25-Dehydro-1alpha(OH)-vitamin D(3)-26,23-lactone (MK) is an antagonist of the 1alpha,25(OH)(2)-vitamin D(3) (1,25D)/human nuclear vitamin D receptor (hVDR) transcription initiation complex, where the activation helix (i.e. helix-12) is closed. To study the...
7.
Sawada D, Katayama T, Tsukuda Y, Saito N, Takano M, Saito H, et al.
Bioorg Med Chem Lett
. 2009 Aug;
19(18):5397-400.
PMID: 19692243
We synthesized and isolated 2 alpha-substituted analogs of 14-epi-previtamin D3 after thermal isomerization at 80 degrees C for the first time. The VDR binding affinity and transactivation activity of osteocalcin...
8.
Kittaka A, Hara H, Takano M, Sawada D, Arai M, Takagi K, et al.
Anticancer Res
. 2009 Aug;
29(9):3563-9.
PMID: 19667149
The 14-epimer of MART-10, namely 14-epi-MART-10 (14-epi-2alpha-(3-hydroxypropyl)-1alpha,25-dihydroxy-19-norvitamin D3) and its 2-epimeric analog (14-epi-MART-11) were efficiently synthesized using the Julia coupling reaction to connect between the C5 and C6 positions (steroid...
9.
Hiruma Y, Kurihara N, Subler M, Zhou H, Boykin C, Zhang H, et al.
Hum Mol Genet
. 2008 Sep;
17(23):3708-19.
PMID: 18765443
Paget's disease of bone (PDB) is the second most common bone disease and is characterized by focal bone lesions which contain large numbers of abnormal osteoclasts (OCLs) and very active...
10.
Cho K, Uneuchi F, Kato-Nakamura Y, Namekawa J, Ishizuka S, Takenouchi K, et al.
Bioorg Med Chem Lett
. 2008 Jul;
18(15):4287-90.
PMID: 18635349
Structure-activity relationship studies on 1alpha,25-dihydroxyvitamin D(3)-26,23-lactams (DLAMs), antagonists of vitamin D, were conducted, focusing on the substituents of the phenyl group. One of the derivatives (23S,25S)-DLAM-1P-3,5(OEt)(2), showed potent antagonistic activity...