Seetha Mannepalli
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Explore the profile of Seetha Mannepalli including associated specialties, affiliations and a list of published articles.
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14
Citations
397
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Recent Articles
1.
Cerutti G, Arias R, Bahna F, Mannepalli S, Katsamba P, Ahlsen G, et al.
Mol Cell
. 2024 Nov;
84(23):4677-4690.e6.
PMID: 39510067
Sevenless (Sev) is a Drosophila receptor tyrosine kinase (RTK) required for the specification of the R7 photoreceptor. It is cleaved into α and β subunits and binds the ectodomain of...
2.
Zipursky S, Lee J, Sergeeva A, Ahlsen G, Mannepalli S, Bahna F, et al.
Res Sq
. 2024 Mar;
PMID: 38463964
Self-recognition is a fundamental cellular process across evolution and forms the basis of neuronal self-avoidance1-4. Clustered protocadherins (Pcdh), comprising a large family of isoform-specific homophilic recognition molecules, play a pivotal...
3.
Sergeeva A, Katsamba P, Liao J, Sampson J, Bahna F, Mannepalli S, et al.
J Mol Biol
. 2023 Jun;
435(15):168187.
PMID: 37355034
The strength of binding between human angiotensin converting enzyme 2 (ACE2) and the receptor binding domain (RBD) of viral spike protein plays a role in the transmissibility of the SARS-CoV-2...
4.
Xu S, Sergeeva A, Katsamba P, Mannepalli S, Bahna F, Bimela J, et al.
Cell Rep
. 2022 Apr;
39(1):110618.
PMID: 35385751
Neurons in the developing brain express many different cell adhesion molecules (CAMs) on their surfaces. CAM-binding affinities can vary by more than 200-fold, but the significance of these variations is...
5.
Goodman K, Katsamba P, Rubinstein R, Ahlsen G, Bahna F, Mannepalli S, et al.
Elife
. 2022 Mar;
11.
PMID: 35253643
The stochastic expression of fewer than 60 clustered protocadherin (cPcdh) isoforms provides diverse identities to individual vertebrate neurons and a molecular basis for self-/nonself-discrimination. cPcdhs form chains mediated by alternating...
6.
Blockus H, Rolotti S, Szoboszlay M, Peze-Heidsieck E, Ming T, Schroeder A, et al.
Cell Rep
. 2021 Oct;
37(3):109828.
PMID: 34686348
Synaptic connectivity within adult circuits exhibits a remarkable degree of cellular and subcellular specificity. We report that the axon guidance receptor Robo2 plays a role in establishing synaptic specificity in...
7.
Sergeeva A, Katsamba P, Cosmanescu F, Brewer J, Ahlsen G, Mannepalli S, et al.
Nat Commun
. 2020 May;
11(1):2125.
PMID: 32358559
Differential binding affinities among closely related protein family members underlie many biological phenomena, including cell-cell recognition. Drosophila DIP and Dpr proteins mediate neuronal targeting in the fly through highly specific...
8.
Brasch J, Goodman K, Noble A, Rapp M, Mannepalli S, Bahna F, et al.
Nature
. 2019 Apr;
569(7755):280-283.
PMID: 30971825
Neurite self-recognition and avoidance are fundamental properties of all nervous systems. These processes facilitate dendritic arborization, prevent formation of autapses and allow free interaction among non-self neurons. Avoidance among self...
9.
Goodman K, Rubinstein R, Dan H, Bahna F, Mannepalli S, Ahlsen G, et al.
Proc Natl Acad Sci U S A
. 2017 Nov;
114(46):E9829-E9837.
PMID: 29087338
Clustered protocadherins (Pcdhs) mediate numerous neural patterning functions, including neuronal self-recognition and non-self-discrimination to direct self-avoidance among vertebrate neurons. Individual neurons stochastically express a subset of Pcdh isoforms, which assemble...
10.
Goodman K, Rubinstein R, Aye Thu C, Mannepalli S, Bahna F, Ahlsen G, et al.
Elife
. 2016 Oct;
5.
PMID: 27782885
Stochastic cell-surface expression of α-, β-, and γ-clustered protocadherins (Pcdhs) provides vertebrate neurons with single-cell identities that underlie neuronal self-recognition. Here we report crystal structures of ectodomain fragments comprising cell-cell...