Rotem Rubinstein
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Explore the profile of Rotem Rubinstein including associated specialties, affiliations and a list of published articles.
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18
Citations
939
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Recent Articles
1.
Bergson S, Sarig O, Giladi M, Mohamad J, Mogezel-Salem M, Smorodinsky-Atias K, et al.
J Exp Med
. 2025 Feb;
222(5).
PMID: 39976600
Epidermolysis bullosa simplex (EBS) refers to a heterogeneous group of inherited skin disorders characterized by blister formation within the basal cell layer. The disease is characterized by marked variations in...
2.
Wiseglass G, Rubinstein R
Mol Biol Evol
. 2024 Jul;
41(7).
PMID: 38989909
Many adhesion proteins, evolutionarily related through gene duplication, exhibit distinct and precise interaction preferences and affinities crucial for cell patterning. Yet, the evolutionary paths by which these proteins acquire new...
3.
Wiseglass G, Boni N, Smorodinsky-Atias K, Rubinstein R
Proc Natl Acad Sci U S A
. 2024 Jul;
121(29):e2319829121.
PMID: 38976736
In the developing human brain, only 53 stochastically expressed clustered protocadherin (cPcdh) isoforms enable neurites from individual neurons to recognize and self-avoid while simultaneously maintaining contact with neurites from other...
4.
Boni N, Shapiro L, Honig B, Wu Y, Rubinstein R
Proc Natl Acad Sci U S A
. 2022 Aug;
119(34):e2206175119.
PMID: 35969779
Crystal structures of many cell-cell adhesion receptors reveal the formation of linear "molecular zippers" comprising an ordered one-dimensional array of proteins that form both intercellular () and intracellular () interactions....
5.
Goodman K, Katsamba P, Rubinstein R, Ahlsen G, Bahna F, Mannepalli S, et al.
Elife
. 2022 Mar;
11.
PMID: 35253643
The stochastic expression of fewer than 60 clustered protocadherin (cPcdh) isoforms provides diverse identities to individual vertebrate neurons and a molecular basis for self-/nonself-discrimination. cPcdhs form chains mediated by alternating...
6.
Zhou F, Cao G, Dai S, Li G, Li H, Ding Z, et al.
Proc Natl Acad Sci U S A
. 2020 Sep;
117(40):24813-24824.
PMID: 32963097
Thousands of Down syndrome cell adhesion molecule (Dscam1) isoforms and ∼60 clustered protocadhrein (cPcdh) proteins are required for establishing neural circuits in insects and vertebrates, respectively. The strict homophilic specificity...
7.
Dionne G, Qiu X, Rapp M, Liang X, Zhao B, Peng G, et al.
Neuron
. 2018 Jul;
99(3):480-492.e5.
PMID: 30057206
The tip link, a filament formed by protocadherin 15 (PCDH15) and cadherin 23, conveys mechanical force from sound waves and head movement to open hair-cell mechanotransduction channels. Tip-link cadherins are...
8.
Goodman K, Rubinstein R, Dan H, Bahna F, Mannepalli S, Ahlsen G, et al.
Proc Natl Acad Sci U S A
. 2017 Nov;
114(46):E9829-E9837.
PMID: 29087338
Clustered protocadherins (Pcdhs) mediate numerous neural patterning functions, including neuronal self-recognition and non-self-discrimination to direct self-avoidance among vertebrate neurons. Individual neurons stochastically express a subset of Pcdh isoforms, which assemble...
9.
Rubinstein R, Goodman K, Maniatis T, Shapiro L, Honig B
Semin Cell Dev Biol
. 2017 Jul;
69:140-150.
PMID: 28743640
Clustered protocadherins mediate neuronal self-recognition and non-self discrimination-neuronal "barcoding"-which underpin neuronal self-avoidance in vertebrate neurons. Recent structural, biophysical, computational, and cell-based studies on protocadherin structure and function have led to...
10.
Samanta D, Guo H, Rubinstein R, Ramagopal U, Almo S
Mol Immunol
. 2016 Dec;
81:151-159.
PMID: 27978489
In addition to antigen-specific stimulation of T cell receptor (TCR) by a peptide-MHC complex, the functional outcome of TCR engagement is regulated by antigen-independent costimulatory signals. Costimulatory signals are provided...