Sebastien Soubeyrand
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Explore the profile of Sebastien Soubeyrand including associated specialties, affiliations and a list of published articles.
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28
Citations
361
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Recent Articles
1.
Soubeyrand S, Lau P, McPherson R
Front Mol Biosci
. 2025 Feb;
12:1548582.
PMID: 39990870
Introduction: Constitutive Photomorphogenesis Protein 1 homolog (COP1) is a conserved E3 ligase with key roles in several biological systems. Prior work in hepatocyte-derived tumors categorized COP1 as an oncogene, but...
2.
Soubeyrand S, Lau P, Nikpay M, Ma L, Bjorkegren J, McPherson R
Circ Genom Precis Med
. 2024 Dec;
17(6):e004674.
PMID: 39624902
Background: Genome-wide association studies identified a 20-Kb region of chromosome 8 (8q24.13) associated with plasma lipids, hepatic steatosis, and risk for coronary artery disease. The region is proximal to ,...
3.
Soubeyrand S, Lau P, McPherson R
Sci Rep
. 2023 Jun;
13(1):9320.
PMID: 37291259
Tribbles related homolog 1 (TRIB1) contributes to lipid and glucose homeostasis by facilitating the degradation of cognate cargos by the proteasome. In view of the key metabolic role of TRIB1...
4.
Dang A, Turner A, Lau P, Mohottalage D, Stephanie Fong Y, Eriksson P, et al.
Atherosclerosis
. 2022 Apr;
348:8-15.
PMID: 35381443
Background And Aims: Genome-wide association studies (GWAS) identified a coronary artery disease (CAD) risk locus on 13.q34 tagged by rs61969072 (T/G). This variant lies in an intergenic region, proximal to...
5.
Soubeyrand S, Lau P, Nikpay M, Dang A, McPherson R
Circ Genom Precis Med
. 2022 Feb;
15(2):e003428.
PMID: 35130031
Background: Fibronectin () is an essential regulator of homodynamic processes and tissue remodeling that have been proposed to contribute to atherosclerosis. Moreover, recent large-scale genome-wide association studies (GWAS) have linked...
6.
Soubeyrand S, Lau P, Beehler K, McShane K, McPherson R
Sci Rep
. 2021 Dec;
11(1):23748.
PMID: 34887471
We previously identified genomic variants that are quantitative trait loci for circulating miR-1908-5p and then showed this microRNA to causally associate with plasma levels of LDL-C, fasting blood glucose and...
7.
A Common Polymorphism in the Locus Links miR1908 to Low-Density Lipoprotein Cholesterol Through BMP1
Beehler K, Nikpay M, Lau P, Dang A, Lagace T, Soubeyrand S, et al.
Arterioscler Thromb Vasc Biol
. 2021 Jun;
41(8):2252-2262.
PMID: 34134519
OBJECTIVE: Leveraging microRNA-Seq data and the 1000 Genomes imputed genotypes, we identified rs174561 as a strong
microRNA quantitative trait loci for circulating microRNA-1908-5p with higher miR-1908-5p and reduced LDL (lowdensity...
8.
Karunakaran D, Turner A, Duchez A, Soubeyrand S, Rasheed A, Smyth D, et al.
Nat Metab
. 2020 Oct;
2(10):1181.
PMID: 33033401
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
9.
Karunakaran D, Turner A, Duchez A, Soubeyrand S, Rasheed A, Smyth D, et al.
Nat Metab
. 2020 Sep;
2(10):1113-1125.
PMID: 32989316
Obesity is a major public health burden worldwide and is characterized by chronic low-grade inflammation driven by the cooperation of the innate immune system and dysregulated metabolism in adipose tissue...
10.
Nikpay M, Soubeyrand S, Tahmasbi R, McPherson R
Circ Genom Precis Med
. 2020 Sep;
13(6):e002876.
PMID: 32969717
Background: In this study, we aimed to investigate functional mechanisms underlying coronary artery disease (CAD) loci and find molecular biomarkers for CAD. Methods: We devised a multiomics data analysis approach...