Robert J G Hache
Overview
Explore the profile of Robert J G Hache including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
21
Citations
549
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Kuzmochka C, Abdou H, Hache R, Atlas E
Endocrinology
. 2014 Sep;
155(12):4762-73.
PMID: 25203139
Several drugs currently used in the management of mood disorders, epilepsy (ie, valproic acid), or the control of inflammation (ie, corticosteroids) have been shown to promote visceral obesity in humans...
2.
Abdou H, Atlas E, Hache R
Endocrinology
. 2013 Mar;
154(4):1454-64.
PMID: 23456364
Glucocorticoids promote adipogenesis and contribute to the metabolic syndrome through a number of mechanisms. One of the effectors of glucocorticoid action is the CCAAT/enhancer binding protein β (C/EBPβ). C/EBPβ is...
3.
Abdou H, Atlas E, Hache R
J Biol Chem
. 2011 Apr;
286(24):21488-99.
PMID: 21521687
The CCAAT/enhancer-binding protein β (C/EBPβ) is expressed as three isoforms (LAP*, liver-enriched activating protein (LAP), and liver-enriched inhibitory protein (LIP)) that differentially regulate gene expression. The interplay between LAP*, LAP,...
4.
Tomlinson J, Boudreau A, Wu D, Abdou Salem H, Carrigan A, Gagnon A, et al.
Mol Endocrinol
. 2009 Nov;
24(1):104-13.
PMID: 19887648
Glucocorticoids are synthesized locally in adipose tissue and contribute to metabolic disease through the facilitation of adipose tissue expansion. Here we report that exposure of human primary preadipocytes to glucocorticoids...
5.
Soubeyrand S, Pope L, Hache R
Mol Oncol
. 2009 Oct;
4(1):38-51.
PMID: 19858003
Cytotoxicity of the topoisomerase II (topoII) poison etoposide has been ascribed to the persistent covalent trapping of topoII in DNA cleavage complexes that become lethal as cells replicate their DNA....
6.
Carrigan A, Walther R, Abdou Salem H, Wu D, Atlas E, Lefebvre Y, et al.
J Biol Chem
. 2007 Feb;
282(15):10963-71.
PMID: 17314103
The glucocorticoid receptor (GR) cycles between a naive chaperone-complexed form in the cytoplasm and a transcriptionally active steroid-bound nuclear form. Nuclear import of GR occurs rapidly and is mediated through...
7.
Wiper-Bergeron N, Abdou Salem H, Tomlinson J, Wu D, Hache R
Proc Natl Acad Sci U S A
. 2007 Feb;
104(8):2703-8.
PMID: 17301242
Preadipocyte differentiation in culture is driven by an insulin and cAMP dependant transcriptional cascade which induces the bzip transcription factors C/EBPbeta and C/EBPdelta. We have previously shown that glucocorticoid treatment,...
8.
Tomlinson J, Boudreau A, Wu D, Atlas E, Hache R
Endocrinology
. 2006 Jul;
147(11):5284-93.
PMID: 16873539
Glucocorticoids provide an adipogenic stimulus that is most obvious in the truncal obesity of patients with Cushing's syndrome. Glucocorticoid treatment also strongly potentiates the differentiation of human preadipocytes in culture....
9.
Tao T, Lan J, Lukacs G, Hache R, Kaplan F
Am J Respir Cell Mol Biol
. 2006 Jul;
35(6):668-80.
PMID: 16809634
Antiinflammatory effects of glucocorticoids are critical to treatment of airway inflammation in such common disorders as asthma. There is considerable variation in responsiveness to glucocorticoid, and prolonged exposure can result...
10.
Soubeyrand S, Pope L, De Chasseval R, Gosselin D, Dong F, de Villartay J, et al.
J Mol Biol
. 2006 Apr;
358(5):1200-11.
PMID: 16600297
Artemis is a nuclear phosphoprotein required for genomic integrity whose phosphorylation is increased subsequent to DNA damage. Artemis phosphorylation by the DNA-dependent protein kinase (DNA-PK) and the association of Artemis...