Ruth McPherson
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Explore the profile of Ruth McPherson including associated specialties, affiliations and a list of published articles.
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220
Citations
25466
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Recent Articles
1.
Soubeyrand S, Lau P, McPherson R
Front Mol Biosci
. 2025 Feb;
12:1548582.
PMID: 39990870
Introduction: Constitutive Photomorphogenesis Protein 1 homolog (COP1) is a conserved E3 ligase with key roles in several biological systems. Prior work in hepatocyte-derived tumors categorized COP1 as an oncogene, but...
2.
Paquette M, Ruel I, Guay S, Al-Baldawi Z, Brisson D, Gaudet D, et al.
J Clin Lipidol
. 2024 Dec;
19(1):105-113.
PMID: 39638644
Background: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disease of low-density lipoprotein cholesterol (LDL-C) metabolism. Despite the devastating effect of this disease on atherosclerotic cardiovascular health, the disease phenotype...
3.
Soubeyrand S, Lau P, Nikpay M, Ma L, Bjorkegren J, McPherson R
Circ Genom Precis Med
. 2024 Dec;
17(6):e004674.
PMID: 39624902
Background: Genome-wide association studies identified a 20-Kb region of chromosome 8 (8q24.13) associated with plasma lipids, hepatic steatosis, and risk for coronary artery disease. The region is proximal to ,...
4.
McPherson R, Adreak N, Sharma A
Can J Cardiol
. 2024 Aug;
40(8S):S26-S34.
PMID: 39111897
In the primary and secondary prevention of atherosclerotic cardiovascular disease (ASCVD), statins are the primary pharmacologic intervention for ASCVD risk reduction. Statins have proven efficacy and safety in reducing cardiovascular...
5.
Brown L, Ruel I, Baass A, Bergeron J, Brunham L, Cermakova L, et al.
JACC Adv
. 2024 Jun;
2(3):100309.
PMID: 38939573
Background: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disease characterized by very high levels of low-density lipoprotein cholesterol (LDL-C). Untreated patients present with extensive xanthomas and premature atherosclerosis. Lipid-lowering...
6.
Al-Baldawi Z, Brown L, Ruel I, Baass A, Bergeron J, Cermakova L, et al.
J Clin Lipidol
. 2024 Jan;
18(2):e189-e196.
PMID: 38281851
Background: Homozygous familial hypercholesterolemia (HoFH) is a rare, autosomal semi-dominant lipid metabolism disorder characterized by extremely high low-density lipoprotein cholesterol (LDL-C) levels and premature cardiovascular disease. The objective of this...
7.
Soubeyrand S, Lau P, McPherson R
Sci Rep
. 2023 Jun;
13(1):9320.
PMID: 37291259
Tribbles related homolog 1 (TRIB1) contributes to lipid and glucose homeostasis by facilitating the degradation of cognate cargos by the proteasome. In view of the key metabolic role of TRIB1...
8.
Khera A, Wang M, Chaffin M, Emdin C, Samani N, Schunkert H, et al.
Circ Genom Precis Med
. 2022 Oct;
15(6):e003598.
PMID: 36215124
Background: A key goal of precision medicine is to disaggregate common, complex diseases into discrete molecular subtypes. Rare coding variants in the low-density lipoprotein receptor gene () are identified in...
9.
Crosier R, McPherson R
CJC Open
. 2022 Aug;
4(8):732-734.
PMID: 36035741
The ketogenic diet (KD) is currently popular for the achievement of weight loss and improvement in glycemic variables. The diet allows consumption of foods high in fat and protein, with...
10.
Pileggi C, Blondin D, Hooks B, Parmar G, Alecu I, Patten D, et al.
EBioMedicine
. 2022 Aug;
83:104192.
PMID: 35965199
Background: Current paradigms for predicting weight loss in response to energy restriction have general validity but a subset of individuals fail to respond adequately despite documented diet adherence. Patients in...