Sebastian Mathea
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Explore the profile of Sebastian Mathea including associated specialties, affiliations and a list of published articles.
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41
Citations
473
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Recent Articles
1.
Weng J, Aoto P, Lorenz R, Wu J, Schmidt S, Manschwetus J, et al.
PLoS Biol
. 2025 Feb;
23(2):e3003017.
PMID: 39899611
[This corrects the article DOI: 10.1371/journal.pbio.3001427.].
2.
Raig N, Surridge K, Sanz-Murillo M, Dederer V, Kramer A, Schwalm M, et al.
bioRxiv
. 2024 Nov;
PMID: 39554022
Aberrant increases in kinase activity of leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease (PD). Numerous LRRK2-selective type-I kinase inhibitors have been developed and some have entered clinical...
3.
Dederer V, Murillo M, Karasmanis E, Hatch K, Chatterjee D, Preuss F, et al.
J Biol Chem
. 2024 Jun;
300(7):107469.
PMID: 38876305
Leucine rich repeat kinase 2 (LRRK2) is a large multidomain protein containing two catalytic domains, a kinase and a GTPase, as well as protein interactions domains, including a WD40 domain....
4.
Raimi O, Ojha H, Ehses K, Dederer V, Lange S, Polo Rivera C, et al.
Sci Adv
. 2024 Jun;
10(23):eadn7191.
PMID: 38848361
Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) are a frequent cause of early-onset Parkinson's disease (PD). Stabilization of PINK1 at the translocase of outer membrane (TOM) complex of damaged mitochondria...
5.
Champire A, Berabez R, Braka A, Cosson A, Corret J, Girardin C, et al.
Eur J Med Chem
. 2024 Apr;
271:116391.
PMID: 38669909
LIM Kinases, LIMK1 and LIMK2, have become promising targets for the development of inhibitors with potential application for the treatment of several major diseases. LIMKs play crucial roles in cytoskeleton...
6.
Murillo M, Suarez A, Dederer V, Chatterjee D, Louro J, Knapp S, et al.
Sci Adv
. 2023 Dec;
9(48):eadk6191.
PMID: 38039358
Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial Parkinson's disease (PD) and a risk factor for the sporadic form. Increased kinase activity was shown in...
7.
Reimer J, Dickey A, Lin Y, Abrisch R, Mathea S, Chatterjee D, et al.
Nat Struct Mol Biol
. 2023 Oct;
30(11):1735-1745.
PMID: 37857821
Leucine Rich Repeat Kinase 1 and 2 (LRRK1 and LRRK2) are homologs in the ROCO family of proteins in humans. Despite their shared domain architecture and involvement in intracellular trafficking,...
8.
Fathalla R, Frohner W, Bader C, Fischer P, Dahlem C, Chatterjee D, et al.
J Med Chem
. 2022 Oct;
65(21):14740-14763.
PMID: 36269107
To develop novel antibiotics, targeting the early steps of cell wall peptidoglycan biosynthesis seems to be a promising strategy that is still underutilized. MurA, the first enzyme in this pathway,...
9.
Hanke T, Mathea S, Woortman J, Salah E, Berger B, Tumber A, et al.
J Med Chem
. 2022 Sep;
65(19):13264-13287.
PMID: 36136092
LIMKs are important regulators of actin and microtubule dynamics, and they play essential roles in many cellular processes. Deregulation of LIMKs has been linked to the development of diverse diseases,...
10.
Malik A, Karapetsas A, Nirujogi R, Chatterjee D, Phung T, Wightman M, et al.
Biochem J
. 2022 Aug;
479(18):1941-1965.
PMID: 36040231
Leucine-rich-repeat-kinase 1 (LRRK1) and its homolog LRRK2 are multidomain kinases possessing a ROC-CORA-CORB containing GTPase domain and phosphorylate distinct Rab proteins. LRRK1 loss of function mutations cause the bone disorder...