Franziska Preuss
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Explore the profile of Franziska Preuss including associated specialties, affiliations and a list of published articles.
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14
Citations
112
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Recent Articles
1.
Wang X, Gotchev D, Fan K, Vega M, Mani N, McGovern-Gooch K, et al.
J Med Chem
. 2024 Oct;
67(21):19623-19667.
PMID: 39453309
The recent global COVID-19 pandemic has highlighted treatments for coronavirus infection as an unmet medical need. The main protease (M) has been an important target for the development of SARS-CoV-2...
2.
Dederer V, Murillo M, Karasmanis E, Hatch K, Chatterjee D, Preuss F, et al.
J Biol Chem
. 2024 Jun;
300(7):107469.
PMID: 38876305
Leucine rich repeat kinase 2 (LRRK2) is a large multidomain protein containing two catalytic domains, a kinase and a GTPase, as well as protein interactions domains, including a WD40 domain....
3.
Schwalm M, Berger L, Meuter M, Vasta J, Corona C, Rohm S, et al.
Front Cell Dev Biol
. 2022 Jun;
10:886537.
PMID: 35721509
E3 ligases constitute a large and diverse family of proteins that play a central role in regulating protein homeostasis by recruiting substrate proteins recruitment domains to the proteasomal degradation machinery....
4.
Kurz C, Preuss F, Tjaden A, Cusack M, Amrhein J, Chatterjee D, et al.
J Med Chem
. 2022 May;
65(11):7799-7817.
PMID: 35608370
Serine/threonine kinase 17A (death-associated protein kinase-related apoptosis-inducing protein kinase 1─DRAK1) is a part of the death-associated protein kinase (DAPK) family and belongs to the so-called dark kinome. Thus, the current...
5.
Preuss F, Chatterjee D, Dederer V, Knapp S, Mathea S
Methods Enzymol
. 2022 May;
667:663-683.
PMID: 35525558
Pseudokinases play significant roles in disease development. Similar to active kinases, their cellular functions can be targeted pharmacologically. But notably, instead of inhibiting an enzymatic activity, drug-like molecules act by...
6.
Chatterjee D, Preuss F, Dederer V, Knapp S, Mathea S
Cells
. 2022 Jan;
11(1).
PMID: 35011704
Malfunction of the actin cytoskeleton is linked to numerous human diseases including neurological disorders and cancer. LIMK1 (LIM domain kinase 1) and its paralogue LIMK2 are two closely related kinases...
7.
Drewry D, Annor-Gyamfi J, Wells C, Pickett J, Dederer V, Preuss F, et al.
J Med Chem
. 2021 Aug;
65(2):1313-1328.
PMID: 34333981
The pyrimidine core has been utilized extensively to construct kinase inhibitors, including eight FDA-approved drugs. Because the pyrimidine hinge-binding motif is accommodated by many human kinases, kinome-wide selectivity of resultant...
8.
Wanior M, Preuss F, Ni X, Kramer A, Mathea S, Gobel T, et al.
J Med Chem
. 2020 Nov;
63(23):14680-14699.
PMID: 33216538
Accessibility of the human genome is modulated by the ATP-driven SWI/SNF chromatin remodeling multiprotein complexes BAF (BRG1/BRM-associated factor) and PBAF (polybromo-associated BAF factor), which involves reading of acetylated histone tails...
9.
Preuss F, Chatterjee D, Mathea S, Shrestha S, St-Germain J, Saha M, et al.
Structure
. 2020 Aug;
28(11):1184-1196.e6.
PMID: 32814032
Unc-51-like kinase 4 (ULK4) is a pseudokinase that has been linked to the development of several diseases. Even though sequence motifs required for ATP binding in kinases are lacking, ULK4...
10.
Sheetz J, Mathea S, Karvonen H, Malhotra K, Chatterjee D, Niininen W, et al.
Mol Cell
. 2020 Jul;
79(3):390-405.e7.
PMID: 32619402
Despite their apparent lack of catalytic activity, pseudokinases are essential signaling molecules. Here, we describe the structural and dynamic properties of pseudokinase domains from the Wnt-binding receptor tyrosine kinases (PTK7,...