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Sebastiaan H Meijsing

Explore the profile of Sebastiaan H Meijsing including associated specialties, affiliations and a list of published articles. Areas
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Articles 27
Citations 1035
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Recent Articles
11.
Thormann V, Rothkegel M, Schopflin R, Glaser L, Djuric P, Li N, et al.
Nucleic Acids Res . 2018 Feb; 46(6):2868-2882. PMID: 29385519
Genomic binding of transcription factors, like the glucocorticoid receptor (GR), is linked to the regulation of genes. However, as we show here, GR binding is a poor predictor of GR-dependent...
12.
Birth P, Schone S, Stelzl U, Meijsing S
PLoS One . 2017 Jul; 12(7):e0181219. PMID: 28708849
The ability of the glucocorticoid receptor (GR) to regulate the transcriptional output of genes relies on its interactions with transcriptional coregulators. However, which coregulators are required for GR-dependent activation is...
13.
Klassen C, Karabinskaya A, Dejager L, Vettorazzi S, Van Moorleghem J, Luhder F, et al.
J Immunol . 2017 May; 199(1):48-61. PMID: 28515280
Although glucocorticoids (GCs) are a mainstay in the clinical management of asthma, the target cells that mediate their therapeutic effects are unknown. Contrary to our expectation, we found that GC...
14.
Love M, Huska M, Jurk M, Schopflin R, Starick S, Schwahn K, et al.
Nucleic Acids Res . 2016 Dec; 45(4):1805-1819. PMID: 27903902
The genomic loci bound by the glucocorticoid receptor (GR), a hormone-activated transcription factor, show little overlap between cell types. To study the role of chromatin and sequence in specifying where...
15.
Schone S, Jurk M, Bagherpoor Helabad M, Dror I, Lebars I, Kieffer B, et al.
Nat Commun . 2016 Nov; 7:13784. PMID: 27873998
No abstract available.
16.
Schone S, Jurk M, Bagherpoor Helabad M, Dror I, Lebars I, Kieffer B, et al.
Nat Commun . 2016 Sep; 7:12621. PMID: 27581526
The glucocorticoid receptor (GR) binds as a homodimer to genomic response elements, which have particular sequence and shape characteristics. Here we show that the nucleotides directly flanking the core-binding site,...
17.
Batalha V, Ferreira D, Coelho J, Valadas J, Gomes R, Temido-Ferreira M, et al.
Sci Rep . 2016 Aug; 6:31493. PMID: 27510168
Caffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine A2A receptor (A2AR), which is upregulated in the human forebrain of aged and Alzheimer's disease (AD)...
18.
Telorac J, Prykhozhij S, Schone S, Meierhofer D, Sauer S, Thomas-Chollier M, et al.
Nucleic Acids Res . 2016 Mar; 44(13):6142-56. PMID: 27016732
Out of the myriad of potential DNA binding sites of the glucocorticoid receptor (GR) found in the human genome, only a cell-type specific minority is actually bound, indicating that the...
19.
Meijsing S
Adv Exp Med Biol . 2015 Jul; 872:59-81. PMID: 26215990
One fascinating aspect of glucocorticoid signaling is their broad range of physiological and pharmacological effects. These effects are at least in part a consequence of transcriptional regulation by the glucocorticoid...
20.
Starick S, Ibn-Salem J, Jurk M, Hernandez C, Love M, Chung H, et al.
Genome Res . 2015 Feb; 25(6):825-35. PMID: 25720775
The classical DNA recognition sequence of the glucocorticoid receptor (GR) appears to be present at only a fraction of bound genomic regions. To identify sequences responsible for recruitment of this...