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Sebastiaan H Meijsing

Explore the profile of Sebastiaan H Meijsing including associated specialties, affiliations and a list of published articles. Areas
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Articles 27
Citations 1035
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Recent Articles
1.
Glaser L, Steiger M, Fuchs A, van Bommel A, Einfeldt E, Chung H, et al.
Nucleic Acids Res . 2021 Dec; 49(21):12178-12195. PMID: 34850108
Embryonic stem cells (ESCs) can differentiate into any given cell type and therefore represent a versatile model to study the link between gene regulation and differentiation. To quantitatively assess the...
2.
Bothe M, Buschow R, Meijsing S
Life Sci Alliance . 2021 Aug; 4(10). PMID: 34446533
Glucocorticoids are stress hormones that elicit cellular responses by binding to the glucocorticoid receptor, a ligand-activated transcription factor. The exposure of cells to this hormone induces wide-spread changes in the...
3.
Kulik M, Bothe M, Kibar G, Fuchs A, Schone S, Prekovic S, et al.
Nucleic Acids Res . 2021 Mar; 49(7):3856-3875. PMID: 33751115
The glucocorticoid (GR) and androgen (AR) receptors execute unique functions in vivo, yet have nearly identical DNA binding specificities. To identify mechanisms that facilitate functional diversification among these transcription factor...
4.
Ramisch A, Heinrich V, Glaser L, Fuchs A, Yang X, Benner P, et al.
Genome Biol . 2019 Nov; 20(1):227. PMID: 31699133
We present the software Condition-specific Regulatory Units Prediction (CRUP) to infer from epigenetic marks a list of regulatory units consisting of dynamically changing enhancers with their target genes. The workflow...
5.
Li H, Kaiser T, Borschiwer M, Bohnenberger H, Reichardt S, Luhder F, et al.
J Steroid Biochem Mol Biol . 2019 Sep; 195:105485. PMID: 31561002
Glucocorticoids (GCs) play an important role in controlling acute graft-versus-host disease (aGvHD), a frequent complication of allogeneic hematopoietic stem cell transplantation. The anti-inflammatory activity of GCs is mainly ascribed to...
6.
Malik V, Glaser L, Zimmer D, Velychko S, Weng M, Holzner M, et al.
Nat Commun . 2019 Aug; 10(1):3477. PMID: 31375664
Oct4, along with Sox2 and Klf4 (SK), can induce pluripotency but structurally similar factors like Oct6 cannot. To decode why Oct4 has this unique ability, we compare Oct4-binding, accessibility patterns...
7.
Thormann V, Glaser L, Rothkegel M, Borschiwer M, Bothe M, Fuchs A, et al.
Life Sci Alliance . 2019 Mar; 2(2). PMID: 30867223
The glucocorticoid receptor (GR), a hormone-activated transcription factor, binds to a myriad of genomic binding sites yet seems to regulate a much smaller number of genes. Genome-wide analysis of GR...
8.
Schone S, Bothe M, Einfeldt E, Borschiwer M, Benner P, Vingron M, et al.
PLoS Genet . 2018 Nov; 14(11):e1007793. PMID: 30427832
The binding of transcription factors to short recognition sequences plays a pivotal role in controlling the expression of genes. The sequence and shape characteristics of binding sites influence DNA binding...
9.
Tolkachov A, Fischer C, Ambrosi T, Bothe M, Han C, Muenzner M, et al.
Mol Cell Biol . 2018 Mar; 38(12). PMID: 29581184
The transcription factor GATA2 is required for expansion and differentiation of hematopoietic stem cells (HSCs). In mesenchymal stem cells (MSCs), GATA2 blocks adipogenesis, but its biological relevance and underlying genomic...
10.
Thormann V, Rothkegel M, Schopflin R, Glaser L, Djuric P, Li N, et al.
Nucleic Acids Res . 2018 Feb; 46(6):3258. PMID: 29471333
No abstract available.