Sean R McCutcheon
Overview
Explore the profile of Sean R McCutcheon including associated specialties, affiliations and a list of published articles.
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6
Citations
55
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Recent Articles
1.
Rohm D, Black J, McCutcheon S, Barrera A, Berry S, Morone D, et al.
Cell Genom
. 2025 Feb;
5(2):100770.
PMID: 39947136
Epigenome editing with DNA-targeting technologies such as CRISPR-dCas9 can be used to dissect gene regulatory mechanisms and potentially treat associated disorders. For example, Prader-Willi syndrome (PWS) results from loss of...
2.
McCutcheon S, Rohm D, Iglesias N, Gersbach C
Nat Biotechnol
. 2024 Jul;
42(8):1199-1217.
PMID: 39075148
Epigenome editing has rapidly evolved in recent years, with diverse applications that include elucidating gene regulation mechanisms, annotating coding and noncoding genome functions and programming cell state and lineage specification....
3.
Rohm D, Black J, McCutcheon S, Barrera A, Morone D, Nuttle X, et al.
bioRxiv
. 2024 Mar;
PMID: 38496583
Epigenome editing with DNA-targeting technologies such as CRISPR-dCas9 can be used to dissect gene regulatory mechanisms and potentially treat associated disorders. For example, Prader-Willi Syndrome (PWS) is caused by loss...
4.
McCutcheon S, Swartz A, Brown M, Barrera A, McRoberts Amador C, Siklenka K, et al.
Nat Genet
. 2023 Nov;
55(12):2211-2223.
PMID: 37945901
Clinical response to adoptive T cell therapies is associated with the transcriptional and epigenetic state of the cell product. Thus, discovery of regulators of T cell gene networks and their...
5.
McCutcheon S, Swartz A, Brown M, Barrera A, McRoberts Amador C, Siklenka K, et al.
bioRxiv
. 2023 May;
PMID: 37205457
The clinical response to adoptive T cell therapies is strongly associated with transcriptional and epigenetic state. Thus, technologies to discover regulators of T cell gene networks and their corresponding phenotypes...
6.
Black J, McCutcheon S, Dube S, Barrera A, Klann T, Rice G, et al.
Cell Rep
. 2020 Dec;
33(9):108460.
PMID: 33264623
Technologies to reprogram cell-type specification have revolutionized the fields of regenerative medicine and disease modeling. Currently, the selection of fate-determining factors for cell reprogramming applications is typically a laborious and...
7.
McCutcheon S, Chiu K, Lewis D, Tan C
Biotechnol J
. 2017 Nov;
13(5):e1700167.
PMID: 29149479
Reducing leaky gene expression is critical for improving protein yield of recombinant bacteria and stability of engineered cellular circuits in synthetic biology. Leaky gene expression occurs when a genetic promoter...