Charles A Gersbach
Overview
Explore the profile of Charles A Gersbach including associated specialties, affiliations and a list of published articles.
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Articles
134
Citations
10169
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Recent Articles
1.
Butterfield G, Rohm D, Roberts A, Nethery M, Rizzo A, Morone D, et al.
Proc Natl Acad Sci U S A
. 2025 Mar;
122(11):e2417674122.
PMID: 40073054
CRISPR-Cas9 systems have revolutionized biotechnology, creating diverse new opportunities for biomedical research and therapeutic genome and epigenome editing. Despite the abundance of bacterial CRISPR-Cas9 systems, relatively few are effective in...
2.
Rohm D, Black J, McCutcheon S, Barrera A, Berry S, Morone D, et al.
Cell Genom
. 2025 Feb;
5(2):100770.
PMID: 39947136
Epigenome editing with DNA-targeting technologies such as CRISPR-dCas9 can be used to dissect gene regulatory mechanisms and potentially treat associated disorders. For example, Prader-Willi syndrome (PWS) results from loss of...
3.
Shapiro D, Deshpande S, Eghtesadi S, Zhong M, Fontes C, Fiflis D, et al.
Nat Chem
. 2025 Feb;
17(3):448-456.
PMID: 39929988
Biomolecular condensates composed of proteins and RNA are one approach by which cells regulate post-transcriptional gene expression. Their formation typically involves the phase separation of intrinsically disordered proteins with a...
4.
Hernandez Rodriguez M, Biswas D, Slyne A, Lee J, Scarrow E, Abdelbarr S, et al.
PLoS One
. 2025 Feb;
20(2):e0316295.
PMID: 39919154
Duchenne muscular dystrophy (DMD) is an X-linked devastating disease caused by a lack of dystrophin which results in progressive muscle weakness. As muscle weakness progresses, respiratory insufficiency and hypoventilation result...
5.
Liu S, Hamilton M, Cowart T, Barrera A, Bounds L, Nelson A, et al.
Cell Genom
. 2025 Feb;
5(2):100766.
PMID: 39914388
Single-cell RNA sequencing CRISPR (perturb-seq) screens enable high-throughput investigation of the genome, allowing for characterization of thousands of genomic perturbations on gene expression. Ambient gRNAs, which are contaminating gRNAs, are...
6.
Liu S, Hamilton M, Cowart T, Barrera A, Bounds L, Nelson A, et al.
bioRxiv
. 2024 Sep;
PMID: 39282389
Recent technological developments in single-cell RNA-seq CRISPR screens enable high-throughput investigation of the genome. Through transduction of a gRNA library to a cell population followed by transcriptomic profiling by scRNA-seq,...
7.
Chen J, Su S, Pickar-Oliver A, Chiarella A, Hahn Q, Goldfarb D, et al.
Nucleic Acids Res
. 2024 Sep;
52(19):11536-11551.
PMID: 39228373
As a potent and convenient genome-editing tool, Cas9 has been widely used in biomedical research and evaluated in treating human diseases. Numerous engineered variants of Cas9, dCas9 and other related...
8.
Gao Y, Shonai D, Trn M, Zhao J, Soderblom E, Garcia-Moreno S, et al.
Nat Commun
. 2024 Aug;
15(1):6801.
PMID: 39122707
One of the main drivers of autism spectrum disorder is risk alleles within hundreds of genes, which may interact within shared but unknown protein complexes. Here we develop a scalable...
9.
McCutcheon S, Rohm D, Iglesias N, Gersbach C
Nat Biotechnol
. 2024 Jul;
42(8):1199-1217.
PMID: 39075148
Epigenome editing has rapidly evolved in recent years, with diverse applications that include elucidating gene regulation mechanisms, annotating coding and noncoding genome functions and programming cell state and lineage specification....
10.
Roger A, Biswas D, Huston M, Le D, Bailey A, Pucci L, et al.
Respir Physiol Neurobiol
. 2024 May;
326:104282.
PMID: 38782084
Duchenne muscular dystrophy (DMD) is the most common X-linked disease. DMD is caused by a lack of dystrophin, a critical structural protein in striated muscle. Dystrophin deficiency leads to inflammation,...