Timothy E Reddy
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Explore the profile of Timothy E Reddy including associated specialties, affiliations and a list of published articles.
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74
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7788
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Recent Articles
1.
Moore J, Pratt H, Fan K, Phalke N, Fisher J, Elhajjajy S, et al.
bioRxiv
. 2025 Jan;
PMID: 39763870
Mammalian genomes contain millions of regulatory elements that control the complex patterns of gene expression. Previously, The ENCODE consortium mapped biochemical signals across many cell types and tissues and integrated...
2.
Beaman M, Yin W, Smith A, Sears P, Leigh M, Ferkol T, et al.
Am J Med Genet A
. 2024 Oct;
197(2):e63880.
PMID: 39364610
Variation in the non-coding genome represents an understudied mechanism of disease and it remains challenging to predict if single nucleotide variants, small insertions and deletions, or structural variants in non-coding...
3.
Zou X, Gomez Z, Reddy T, Allen A, Majoros W
bioRxiv
. 2024 Aug;
PMID: 39211106
Motivation: Allele-specific expression (ASE) analyses aim to detect imbalanced expression of maternal versus paternal copies of an autosomal gene. Such allelic imbalance can result from a variety of cis-acting causes,...
4.
Melore S, Hamilton M, Reddy T
bioRxiv
. 2024 Jul;
PMID: 39026853
Interactions between multiple genes or cis-regulatory elements (CREs) underlie a wide range of biological processes in both health and disease. High-throughput screens using dCas9 fused to epigenome editing domains have...
5.
Nussbaum D, Martz C, Waters A, Barrera A, Liu A, Rutter J, et al.
NPJ Precis Oncol
. 2024 May;
8(1):124.
PMID: 38822082
Acquired resistance remains a major challenge for therapies targeting oncogene activated pathways. KRAS is the most frequently mutated oncogene in human cancers, yet strategies targeting its downstream signaling kinases have...
6.
Yao D, Tycko J, Oh J, Bounds L, Gosai S, Lataniotis L, et al.
Nat Methods
. 2024 Mar;
21(4):723-734.
PMID: 38504114
The ENCODE Consortium's efforts to annotate noncoding cis-regulatory elements (CREs) have advanced our understanding of gene regulatory landscapes. Pooled, noncoding CRISPR screens offer a systematic approach to investigate cis-regulatory mechanisms....
7.
McCutcheon S, Swartz A, Brown M, Barrera A, McRoberts Amador C, Siklenka K, et al.
Nat Genet
. 2023 Nov;
55(12):2211-2223.
PMID: 37945901
Clinical response to adoptive T cell therapies is associated with the transcriptional and epigenetic state of the cell product. Thus, discovery of regulators of T cell gene networks and their...
8.
Park E, Barclay W, Barrera A, Liao T, Salzler H, Reddy T, et al.
Sci Immunol
. 2023 Oct;
8(88):eadg7597.
PMID: 37831759
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) caused by CNS-infiltrating leukocytes, including T17 cells that are critical mediators of disease pathogenesis. Although targeting leukocyte...
9.
Ang H, Sutiman N, Deng X, Liu A, Cerda-Smith C, Hutchinson H, et al.
Proc Natl Acad Sci U S A
. 2023 Sep;
120(38):e2221448120.
PMID: 37695916
Evidence has long suggested that epidermal growth factor receptor (EGFR) may play a prominent role in triple-negative breast cancer (TNBC) pathogenesis, but clinical trials of EGFR inhibitors have yielded disappointing...
10.
McCutcheon S, Swartz A, Brown M, Barrera A, McRoberts Amador C, Siklenka K, et al.
bioRxiv
. 2023 May;
PMID: 37205457
The clinical response to adoptive T cell therapies is strongly associated with transcriptional and epigenetic state. Thus, technologies to discover regulators of T cell gene networks and their corresponding phenotypes...