Sean P Henry
Overview
Explore the profile of Sean P Henry including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
23
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0
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Recent Articles
1.
Henry S, Jorgensen W
J Med Chem
. 2023 Aug;
66(16):10959-10990.
PMID: 37578217
The Janus kinases (JAKs) are key components of the JAK-STAT signaling pathway and are involved in myriad physiological processes. Though they are the molecular targets of many FDA-approved drugs, these...
2.
Henry S, Liosi M, Ippolito J, Menges F, Newton A, Schlessinger J, et al.
ACS Med Chem Lett
. 2022 Nov;
13(11):1819-1826.
PMID: 36385940
Probe molecules that covalently modify the JAK2 pseudokinase domain (JH2) are reported. Selective targeting of JH2 domains over the kinase (JH1) domains is a necessary feature for ligands intended to...
3.
Liosi M, Ippolito J, Henry S, Krimmer S, Newton A, Cutrona K, et al.
J Med Chem
. 2022 Jun;
65(12):8380-8400.
PMID: 35653642
JAK2 is a non-receptor tyrosine kinase that regulates hematopoiesis through the JAK-STAT pathway. The pseudokinase domain (JH2) is an important regulator of the activity of the kinase domain (JH1). V617F...
4.
Henry S, Liosi M, Ippolito J, Cutrona K, Krimmer S, Newton A, et al.
ACS Med Chem Lett
. 2022 May;
13(5):819-826.
PMID: 35586418
The Janus kinase 2 (JAK2) pseudokinase domain (JH2) is an ATP-binding domain that regulates the activity of the catalytic tyrosine kinase domain (JH1). Dysregulation of JAK2 JH1 signaling caused by...
5.
Newton A, Liosi M, Henry S, Deiana L, Faver J, Krimmer S, et al.
Tetrahedron Lett
. 2021 Aug;
77.
PMID: 34393283
Small molecules that selectively bind to the pseudokinase JH2 domain over the JH1 kinase domain of JAK2 kinase are sought. Virtual screening led to the purchase of 17 compounds among...
6.
Henry S, Fernandez T, Anand J, Griggs N, Traynor J, Mosberg H
J Med Chem
. 2019 Mar;
62(8):4142-4157.
PMID: 30924650
We have previously reported a series of μ-opioid receptor (MOR) agonist/δ-opioid receptor (DOR) antagonist ligands to serve as potential nonaddictive opioid analgesics. These ligands have been shown to be active...