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Joseph A Ippolito

Explore the profile of Joseph A Ippolito including associated specialties, affiliations and a list of published articles. Areas
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Articles 48
Citations 874
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Recent Articles
1.
Ippolito J, Thomson J, Lelkes V, Amer K, Patterson F, Benevenia J, et al.
Ann Jt . 2024 Mar; 7:13. PMID: 38529135
Background: Treatment of metastatic lesions to the humerus is dependent on patient's pain, lesion size and location, and post-operative functional goals. Surgical options include plate or nail fixation [open reduction...
2.
Kadkoy Y, Ippolito J, Schneider G, Thomson J, Park C, Dias R, et al.
J Surg Oncol . 2024 Jan; 129(5):995-999. PMID: 38221660
Background And Objectives: With continued advances in treatment options, patients with endoprosthetic reconstruction are living longer and consequently relying upon their devices for a longer duration. Major causes of endoprosthesis...
3.
Hollander K, Chan A, Frey K, Hunker O, Ippolito J, Spasov K, et al.
Protein Sci . 2023 Oct; 32(12):e4814. PMID: 37861472
HIV-1 reverse transcriptase (RT) remains a key target for HIV drug development. As successful management of the disease requires lifelong treatment, the emergence of resistance mutations is inevitable, making development...
4.
Gupta A, Meeter A, Norin J, Ippolito J, Beebe K
J Orthop Res . 2022 Nov; 41(7):1600-1606. PMID: 36403125
Objectively measuring research output is important for grant awards, promotion, and tenure, or self-evaluation of productivity. However, certain shortcomings limit common bibliometric indicators. The time- and field-independent relative citation ratio...
5.
Henry S, Liosi M, Ippolito J, Menges F, Newton A, Schlessinger J, et al.
ACS Med Chem Lett . 2022 Nov; 13(11):1819-1826. PMID: 36385940
Probe molecules that covalently modify the JAK2 pseudokinase domain (JH2) are reported. Selective targeting of JH2 domains over the kinase (JH1) domains is a necessary feature for ligands intended to...
6.
Batko B, Ippolito J, Gupta A, Bukowiec L, Potter J, Joshi T, et al.
J Orthop . 2022 Sep; 34:226-232. PMID: 36120477
Background: There are numerous strategies to combat postoperative analgesia and expedite recovery after total knee arthroplasty (TKA). The purpose of this study was to determine opioid consumption, length of stay,...
7.
Ippolito J, Siracuse B, Galloway J, Ahmed I, Vosbikian M
Orthopedics . 2022 Aug; 45(6):345-352. PMID: 35947454
Previous studies have defined risk factors for development of venous thromboembolisms (VTEs) among patients with lower extremity orthopedic trauma. Limited data exist on this risk after upper extremity orthopedic trauma....
8.
Liosi M, Ippolito J, Henry S, Krimmer S, Newton A, Cutrona K, et al.
J Med Chem . 2022 Jun; 65(12):8380-8400. PMID: 35653642
JAK2 is a non-receptor tyrosine kinase that regulates hematopoiesis through the JAK-STAT pathway. The pseudokinase domain (JH2) is an important regulator of the activity of the kinase domain (JH1). V617F...
9.
Henry S, Liosi M, Ippolito J, Cutrona K, Krimmer S, Newton A, et al.
ACS Med Chem Lett . 2022 May; 13(5):819-826. PMID: 35586418
The Janus kinase 2 (JAK2) pseudokinase domain (JH2) is an ATP-binding domain that regulates the activity of the catalytic tyrosine kinase domain (JH1). Dysregulation of JAK2 JH1 signaling caused by...
10.
Frey K, Bertoletti N, Chan A, Ippolito J, Bollini M, Spasov K, et al.
Front Mol Biosci . 2022 Mar; 9:805187. PMID: 35237658
Reverse transcriptase (RT) from the human immunodeficiency virus continues to be an attractive drug target for antiretroviral therapy. June 2022 will commemorate the 30th anniversary of the first Human Immunodeficiency...