Sean A McKenna
Overview
Explore the profile of Sean A McKenna including associated specialties, affiliations and a list of published articles.
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58
Citations
1344
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Recent Articles
1.
Koul A, Gemmill D, Lubna N, Meier M, Krahn N, Booy E, et al.
Biophys J
. 2025 Mar;
PMID: 40086432
No abstract available.
2.
Gussakovsky D, Black N, Booy E, McKenna S
RNA Biol
. 2024 Nov;
21(1):1-12.
PMID: 39563162
SRP9/SRP14 is a protein heterodimer that plays a critical role in the signal recognition particle through its interaction with the scaffolding signal recognition particle RNA (7SL). SRP9/SRP14 binding to 7SL...
3.
Booy E, Gussakovsky D, Brown M, Shwaluk R, Nachtigal M, McKenna S
RNA
. 2024 Aug;
30(11):1477-1494.
PMID: 39179355
The noncoding RNA BC200 is elevated in human cancers and is implicated in translation regulation as well as cell survival and proliferation. Upon BC200 overexpression, we observed correlated expression of...
4.
Koul A, Hui L, Lubna N, McKenna S
Biochem Cell Biol
. 2024 Apr;
102(4):305-318.
PMID: 38603810
The 2'-5'-oligoadenylate synthetases (OAS) are important components of the innate immune system that recognize viral double-stranded RNA (dsRNA). Upon dsRNA binding, OAS generate 2'-5'-linked oligoadenylates (2-5A) that activate ribonuclease L...
5.
Thind S, Lima D, Booy E, Trinh D, McKenna S, Kuss S
Proc Natl Acad Sci U S A
. 2023 Dec;
121(1):e2310288120.
PMID: 38154062
Cytochrome oxidase deficiency (COXD) is an inherited disorder characterized by the absence or mutation in the genes encoding for the cytochrome oxidase protein (COX). COX deficiency results in severe muscle...
6.
Lozada I, Gussakovsky D, Jayawardhana A, McKenna S, Zheng Y, Herbert D
Photochem Photobiol Sci
. 2023 Sep;
22(11):2587-2597.
PMID: 37725299
Pt(II) complexes supported by chelating, multidentate ligands containing π-extended, planar phenanthridine (benzo[c]quinoline) donors (LPtCl) exhibit a promising in vitro therapeutic index compared with phenanthriplatin, a leading preclinical anticancer complex containing...
7.
Gussakovsky D, Booy E, Brown M, McKenna S
RNA
. 2023 May;
29(8):1185-1200.
PMID: 37156570
The SRP9/SRP14 heterodimer is a central component of signal recognition particle (SRP) RNA (7SL) processing and Alu retrotransposition. In this study, we sought to establish the role of nuclear SRP9/SRP14...
8.
Gussakovsky D, McKenna S
RNA Biol
. 2021 Oct;
18(sup2):574-585.
PMID: 34672903
Alu RNA are implicated in the poor prognosis of several human disease states. These RNA are transcription products of primate specific transposable elements called Alu elements. These elements are extremely...
9.
Dupas S, Gussakovsky D, Wai A, Brown M, Hausner G, McKenna S
Biochem Cell Biol
. 2021 Feb;
99(5):536-553.
PMID: 33587669
RNA quadruplexes are non-canonical nucleic acid structures involved in several human disease states and are regulated by a specific subset of RNA helicases. Given the difficulty in identifying RNA quadruplex...
10.
Booy E, Gussakovsky D, Choi T, McKenna S
J Biol Chem
. 2021 Jan;
296:100036.
PMID: 33410401
BC200 is a noncoding RNA elevated in a broad spectrum of tumor cells that is critical for cell viability, invasion, and migration. Overexpression studies have implicated BC200 and the rodent...